Thermo Scientific™

NanoDrop™ One/OneC Microvolume UV-Vis Spectrophotometer

NanoDrop&trade; One/One<sup>C</sup> Microvolume UV-Vis Spectrophotometer
Prevent costly delays with an enhanced understanding of sample quality using the Thermo Scientific™ NanoDrop™ One Microvolume UV-Vis Spectrophotometers. Innovative Thermo Scientific™ Acclaro™ Sample Intelligence technology is built into every instrument for improved measurement accuracy and contaminant identification. Quantify and qualify DNA, RNA, and protein samples  in seconds with only 1-2 µL, and obtain full-spectral data before you decide to use samples in downstream applications. Additional cuvette position also available.
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Move one step closer to your research goals with an ergonomic, standalone spectrophotometer with high-resolution, touch screen interface. Powerful auto-range pathlength technology facilitates accurate measurements for concentrated samples with no need for dilutions. This is your innovative alternative to the NanoDrop 2000/2000c spectrophotometers.


Acclaro Sample Intelligence Technology
  • Acclaro technology enhances user understanding of sample quality while delivering accurate quantitative measurements. Early identification of contaminants can prevent failure of downstream applications and save days of troubleshooting.
  • Verify sample quality in seconds - identify sample contaminants and obtain corrected concentration results.
  • Access information through alerts – receive instant feedback about sample quality with on-demand technical support and guided troubleshooting.
  • Rely on accurate results – ensure measurement integrity with embedded sensor and digital image analysis.

NanoDrop One/NanoDrop OneC Enhancements
  • Ergonomic, standalone design – integrated Android™ tablet eliminates the need for a separate computer and provides seamless data transfer via Wireless*, Ethernet or USB.
  • Auto-Measure and Auto-Blank functions – multi-sample processing can be streamlined with instant measurements that occur when the pedestal arm is down. These functions can be turned ON or OFF with a single tap on the screen.
  • Wider dynamic range – no dilutions required for highly concentrated samples (dsDNA at 27,500 ng/µL) with auto-range pathlength technology
  • Integrated Learning Center - an archive of technical support documents and educational animations at your fingertips.

Advanced Connectivity for Data Storage, Printing and Sharing
  • Multiple choices for data export: transfer results with a USB, Wi-Fi or Ethernet connection to your PC or save data directly to the Thermo Fisher Cloud via Wi-Fi or Ethernet network.
  • View, organize and share data on a PC: Once exported, you can view the full-data formats (e.g., contaminant analysis spectral graphs) and organize experiments using the NanoDrop One/OneC PC Control software.
  • Easy data-to-printer options: Print your results directly from the NanoDrop One instrument via Wi-Fi, Ethernet or USB printer connection; print exported data from your PC using the Nanodrop One/OneC PC Control software.
  • 24/7 access to data: View data anytime, anywhere from any device (Android-based or iOS-based devices, PC or Mac desktop computers) when you collect, analyze, store and share your NanoDrop One data on the NanoDrop App found on the [https://www.thermofisher.com/us/en/home/cloud.html] Thermo Fisher Cloud. Requires registration.
  • Online collaborations: Share data between colleagues who do not have an instrument and view NanoDrop One data across multiple Thermo Fisher Cloud-connected accounts.

NanoDrop OneC Highlights
  • Contains both pedestal and cuvette positions to expand experimental flexibility and increase the dynamic range.
  • Measure dilute samples, perform kinetics experiments and take optical density measurements of bacterial cultures.
  • Cuvette position includes temperature control and stirring.

NanoDrop One/NanoDrop OneC Capabilities
  • Wide spectral range (190-850 nm) for measuring a variety of samples types:
    • Peptides (205 nm)
    • DNA and RNA (260 nm)
    • Purified protein (280 nm)
    • Toxicology assays and industrial dyes (490 nm)
    • Gold nanoparticles (520 nm)
    • Colorimetric protein assays (BCA 562 nm, Bradford 595 nm, Modified Lowry 650 nm, Pierce 660 660 nm)
    • Optical Density measurements (600 nm)
  • Combining the patented** sample-retention system with cuvette capability accommodates low and high concentrations (2.0 - 27,500 ng/µL dsDNA and 0.06 - 820 mg/mL BSA)
  • Pedestal measurements that require only 1 – 2 µL of your sample and do not require sample dilution, even for highly concentrated samples
  • Calculates sample purity ratios (A260/A280 nm and A260/A230 nm)
  • Pre-configured methods for DNA, Protein A280, Microarray, Protein and Labels, Pierce 660, Bradford, BCA, and Lowry
  • User-friendly software includes custom methods and data export capabilities

* Wi-Fi model not available in certain countries – consult your local NanoDrop distributor

**Patents US6628382 and US6809826

For research use only; not for diagnostic purposes.