Thermo Scientific™

BioPharma Finder™ Mass Informatics Platform for Protein Characterization

 Related applications:
Industrial Mass Spectrometry

Save time and identify more with Thermo Scientific™ BioPharma Finder™ software. Screen, identify, and characterize intact proteins with higher productivity and confidence. Confirm amino acid sequence, and identify relative amounts of known/unknown post-translational modifications (PTMs) using the Peptide Mapping workflow. Enable efficient sequence verification, along with identification and localization of modifications by using the automated top-down workflow. All BioPharma Finder software workflows take full advantage of the high-quality, HRAM data produced by Thermo Scientific™ Orbitrap™ mass analyzers.

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Description

Workflow-driven experiment creation, method processing, and result review

Intact protein workflow:

  • Rapidly measure the intact molecular weight of biotherapeutics for structural confirmation and characterization
  • Confidently determine deconvoluted molecular weights in both acidic and native conditions
  • Target protein sequence matching to identify n-linked glycosylations and other common modifications
  • Identify Antibody Drug Conjugates (ADC) using sliding window algorithm
  • Batch-to-batch comparison
  • Detection of low-abundance species

Peptide mapping workflow:

  • Confirm amino acid sequence with a novel MS2 prediction algorithm, providing extra confidence for sequence assignments
  • Identify the site and type of expected and unknown PTMs
  • Map disulfide bonds
  • Detect low-level impurities and sequence variants
  • Identify sequence alterations in stress samples, including the level of deamidation or oxidation
  • Perform error-tolerant searches for unexpected modifications
  • Create de novo sequence searches

Multi Attribute Methods (MAM):

  • MS-based MAM for characterization and relative quantification of PTMs
  • Features streamlined processes ranging from discovery peptide mapping to critical quality attributes (CQAs) monitoring in GMP environments
  • Can be used for clone screening, process development, comparability, and stability assessment

Top down workflow:

  • Features a simple workflow for sequencing intact protein molecules using ProSightBP as the core algorithm
  • Includes multiple raw file comparison with combined interactive fragmentation coverage maps
  • Supports multiple modes of fragmentation CID, HCD, ETD, EThcD and UVPD


Learn more about BioPharma Finder's capabilities

Learn more about BioPharma Finder's capabilities

Understand more about how to get the most out of your protein data, from intact, native intact, top-down through to peptide mapping.

Learn more ›

Documents

Manuals & protocols