A Review of Reagents for Fluorescence Microscopy of Cellular Compartments and Structures, Part I: BacMam Labeling and Reagents for Vesicular Structures.
AuthorsDolman NJ, Kilgore JA, Davidson MW,
Journal
PubMed ID23835803
'Fluorescent labeling of vesicular structures in cultured cells, particularly for live cells, can be challenging for a number of reasons. The first challenge is to identify a reagent that will be specific enough where some structures have a number of potential reagents and others very few options. The emergence of ... More
A modern descendant of early green algal phagotrophs.
AuthorsMaruyama S, Kim E,
Journal
PubMed ID23707430
Green algae, land plants, and other photosynthetic eukaryotes possess plastids, such as chloroplasts, which have evolved from cyanobacterial ancestors via endosymbiosis [1]. An early evolutionary merger between heterotrophic eukaryotes and cyanobacteria called primary endosymbiosis gave rise to the first photosynthetic eukaryotes. A series of plastid acquisitions involving engulfment of eukaryotic phototrophs, ... More
Glutathione reductase is essential for host defense against bacterial infection.
AuthorsYan J, Ralston MM, Meng X, Bongiovanni KD, Jones AL, Benndorf R, Nelin LD, Joshua Frazier W, Rogers LK, Smith CV, Liu Y,
JournalFree Radic Biol Med
PubMed ID23623936
Glutathione reductase (Gsr) catalyzes the reduction of glutathione disulfide to glutathione, a major cellular antioxidant. We have recently shown that Gsr is essential for host defense against the gram-negative bacteria Escherichia coli in a mouse model of sepsis. Although we have demonstrated that Gsr is required for sustaining the oxidative ... More
NFAT signaling in human mesenchymal stromal cells affects extracellular matrix remodeling and antifungal immune responses.
Authors
JournaliScience
PubMed ID34195564
Deficiency of Microglial Autophagy Increases the Density of Oligodendrocytes and Susceptibility to Severe Forms of Seizures.
Authors
JournalEneuro
PubMed ID33472865
A Novel LRRK2 Variant p.G2294R in the WD40 Domain Identified in Familial Parkinson's Disease Affects LRRK2 Protein Levels.
Authors
JournalInt J Mol Sci
PubMed ID33918221
Suppression of trabecular meshwork phagocytosis by norepinephrine is associated with nocturnal increase in intraocular pressure in mice.
Authors
JournalCommun Biol
PubMed ID35396348
Microglial mTOR is Neuronal Protective and Antiepileptogenic in the Pilocarpine Model of Temporal Lobe Epilepsy.
Authors
JournalJ Neurosci
PubMed ID32868461
Lower level noise exposure that produces only TTS modulates the immune homeostasis of cochlear macrophages.
Authors
JournalJ Neuroimmunol
PubMed ID30196827
Lipin-1 Contributes to IL-4 Mediated Macrophage Polarization.
Authors
JournalFront Immunol
PubMed ID32431707
Endocannabinoid System Contributes to Liver Injury and Inflammation by Activation of Bone Marrow-Derived Monocytes/Macrophages in a CB1-Dependent Manner.
Authors
JournalJ Immunol
PubMed ID26320250
Complement inhibitor factor H expressed by breast cancer cells differentiates CD14+ human monocytes into immunosuppressive macrophages.
Authors
JournalOncoimmunology
PubMed ID32923173
Intercellular Calcium Signaling Induced by ATP Potentiates Macrophage Phagocytosis.
Authors
JournalCell Rep
PubMed ID30943393
The Telomerase Complex Directly Controls Hematopoietic Stem Cell Differentiation and Senescence in an Induced Pluripotent Stem Cell Model of Telomeropathy.
Telomeropathies are rare disorders associated with impaired telomere length control mechanisms that frequently result from genetic mutations in the telomerase complex. Dyskeratosis congenita is a congenital progressive telomeropathy in which mutation in the telomerase RNA component ( ... More
Monocyte-to-macrophage switch reversibly impaired by Ibrutinib.
AuthorsFerrarini I, Rigo A, Montresor A, Laudanna C, Vinante F
JournalOncotarget
PubMed ID30956776
Ibrutinib is increasingly adopted for treating lymphoid malignancies. While growing amounts of data pile up about Ibrutinib mechanism of action on neoplastic B cells, little is known about its impact on other immune cells. Here we investigated the effect of Ibrutinib on monocyte/macrophage functions. (1) Ibrutinib treatment of purified human ... More
In vitro gill cell monolayer successfully reproduces in vivo Atlantic salmon host responses to Neoparamoeba perurans infection.
AuthorsCano I, Taylor NG, Bayley A, Gunning S, McCullough R, Bateman K, Nowak BF, Paley RK
JournalFish Shellfish Immunol
PubMed ID30458309
An in vitro model to study the host response to Neoparamoeba perurans, the causative agent of amoebic gill disease (AGD), was evaluated. The rainbow trout gill derived cell line, RTgill-W1, was seeded onto permeable cell culture supports and maintained asymmetrically with apical seawater. Cells were inoculated with either a passage ... More