'Heart failure is a leading cause of death, especially in the elderly or obese and diabetic populations. Various remodeling events have been characterized, which collectively contribute to the progression of heart failure. Of particular interest, autophagy has recently emerged as an important determinant of cardiac remodeling and function. Here, we ... More
The pro-apoptotic role of autophagy in breast cancer.
AuthorsSuman S, Das TP, Reddy R, Nyakeriga AM, Luevano JE, Konwar D, Pahari P, Damodaran C,
Journal
PubMed ID24945999
'Autophagy is a catabolic process that has a vital role in cancer progression and treatment. Current chemotherapeutic agents, which target autophagy, result in growth inhibition in many cancer types. In this study, we examined the role of autophagy in breast cancer (BCa) patients as well as BCa cell lines. Tissue ... More
Spatial coupling of mTOR and autophagy augments secretory phenotypes.
AuthorsNarita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, Hong S, Berry LS, Reichelt S, Ferreira M, Tavaré S, Inoki K, Shimizu S, Narita M,
JournalScience
PubMed ID21512002
'Protein synthesis and autophagic degradation are regulated in an opposite manner by mammalian target of rapamycin (mTOR), whereas under certain conditions it would be beneficial if they occurred in unison to handle rapid protein turnover. We observed a distinct cellular compartment at the trans side of the Golgi apparatus, the ... More
Airway Exposure to E-Cigarette Vapors Impairs Autophagy and Induces Aggresome Formation.
AuthorsShivalingappa PC, Hole R, Westphal CV, Vij N,
Journal
PubMed ID26377848
Electronic cigarettes (e-cigarettes) are proposed to be a safer alternative to tobacco cigarettes. Hence, we evaluated if e-cigarette vapors (eCV) impair cellular proteostasis similar to cigarette smoke exposure. First, we evaluated the impact of eCV exposure (2.5 or 7.5?mg) on Beas2b cells that showed significant increase in accumulation of total ... More
Trehalose intake induces chaperone molecules along with autophagy in a mouse model of Lewy body disease.
AuthorsTanji K, Miki Y, Maruyama A, Mimura J, Matsumiya T, Mori F, Imaizumi T, Itoh K, Wakabayashi K,
Journal
PubMed ID26299928
The accumulation of mis-folded and/or abnormally modified proteins is a major characteristic of many neurodegenerative diseases. In Lewy body disease (LBD), which includes Parkinson's disease and dementia with Lewy bodies, insoluble a-synuclein is widely deposited in the presynaptic terminals as well as in the neuronal cytoplasm in distinct brain regions. ... More
Long-term effectiveness of the Burch colposuspension in female urinary stress incontinence.
Of 91 women who underwent Burch colposuspension, 86 were available for clinical, urodynamic and isotope renographic follow-up examinations 5 years after surgery for evaluation of late complications and long-term effectiveness in urinary stress incontinence. A repeat urodynamic examination was accepted by 76 patients. Stress incontinence was cured in 71% of ... More
Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKα signaling in STK11 mutant lung cancer.
Authors
JournalAutophagy
PubMed ID31232177
ESCRT-0 dysfunction compromises autophagic degradation of protein aggregates and facilitates ER stress-mediated neurodegeneration via apoptotic and necroptotic pathways.
AuthorsOshima R, Hasegawa T, Tamai K, Sugeno N, Yoshida S, Kobayashi J, Kikuchi A, Baba T, Futatsugi A, Sato I, Satoh K, Takeda A, Aoki M, Tanaka N,
JournalSci Rep
PubMed ID27112194
'Endosomal sorting required for transport (ESCRT) complexes orchestrate endo-lysosomal sorting of ubiquitinated proteins, multivesicular body formation and autophagic degradation. Defects in the ESCRT pathway have been implicated in many neurodegenerative diseases, but the underlying molecular mechanisms that link them to neurodegeneration remain unknown. In this study, we showed that forebrain-specific ... More
IL-1 induces p62/SQSTM1 and autophagy in ERa
AuthorsNawas AF, Mistry R, Narayanan S, Thomas-Jardin SE, Ramachandran J, Ravichandran J, Neduvelil E, Luangpanh K, Delk NA
JournalJ Cell Biochem
PubMed ID30324661
'Estrogen receptor a (ERa)'
Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death.
AuthorsLiu B, Cui LS, Zhou B, Zhang LL, Liu ZH, Zhang L
JournalActa Pharmacol Sin
PubMed ID31000770
'Excessive and abnormal vessel growth plays a critical role in the pathogenesis of many diseases, such as cancer. Angiogenesis is one of the hallmarks of cancer growth, invasion, and metastasis. Discovery of novel antiangiogenic agents would provide new insights into the mechanisms of angiogenesis, as well as potential drugs for ... More
The level of evidence, scientific impact and social impact of clinical studies in periodontology: A methodological study.
AuthorsMeng Z, Xiang Q, Wu X, Hua F, Dong W, Tu YK
JournalJ Clin Periodontol
PubMed ID32452044
'To analyse the level of evidence (LOE) of clinical studies in the field of periodontology, and to investigate whether LOE is a predictor of scientific impact and social impact.' ... More
Eicosapentaenoic acid (EPA) activates PPAR? signaling leading to cell cycle exit, lipid accumulation, and autophagy in human meibomian gland epithelial cells (hMGEC).
AuthorsKim SW, Rho CR, Kim J, Xie Y, Prince RC, Mustafa K, Potma EO, Brown DJ, Jester JV
JournalOcul Surf
PubMed ID32360782
'The purpose of this study was to access the ability of the natural PPAR agonist, eicosapentaenoic acid (EPA), to activate PPAR gamma (?) signaling leading to meibocyte differentiation in human meibomian gland epithelial cell (hMGEC).' ... More
AuthorsVij N, Chandramani P, Westphal CV, Hole R, Bodas M,
JournalAm J Physiol Cell Physiol
PubMed ID27413169
'Cigarette-smoke (CS) exposure and aging are the leading causes of chronic obstructive pulmonary disease (COPD)-emphysema development, although the molecular mechanism that mediates disease pathogenesis remains poorly understood. To investigate the impact of CS-exposure and aging on autophagy, and pathophysiological changes associated with lung aging (senescence) and emphysema progression. Beas2b cells, ... More
Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis.
Authors
JournalRedox Biol
PubMed ID32171725
Therapeutic evaluation of palbociclib and its compatibility with other chemotherapies for primary and recurrent nasopharyngeal carcinoma.
Authors
JournalJ Exp Clin Cancer Res
PubMed ID33243298
MLKL-dependent signaling regulates autophagic flux in a murine model of non-alcohol-associated fatty liver and steatohepatitis.
Authors
JournalJ Hepatol
PubMed ID32220583
KIF5A-dependent axonal transport deficiency disrupts autophagic flux in trimethyltin chloride-induced neurotoxicity.
Authors
JournalAutophagy
PubMed ID32160081
Autophagy and post-ischemic conditioning in retinal ischemia.
Authors
JournalAutophagy
PubMed ID32452260
Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation.
Authors
JournalJ Clin Invest
PubMed ID30375985
Therapeutic efficacy of antisense oligonucleotides in mouse models of CLN3 Batten disease.
Authors
JournalNat Med
PubMed ID32719489
Spermine synthase deficiency causes lysosomal dysfunction and oxidative stress in models of Snyder-Robinson syndrome.
Authors
JournalNat Commun
PubMed ID29097652
Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome.
Authors
JournalAutophagy
PubMed ID29979914
Activation of hERG3 channel stimulates autophagy and promotes cellular senescence in melanoma.
AuthorsPerez-Neut M, Haar L, Rao V, Santha S, Lansu K, Rana B, Jones WK, Gentile S,
JournalOncotarget
PubMed ID26942884
Ion channels play a major factor in maintaining cellular homeostasis but very little is known about the role of these proteins in cancer biology. In this work we have discovered that, the Kv11.3 (hERG3) a plasma-membrane potassium channel plays a critical role in the regulation of autophagy in a cancer ... More
Melatonin antagonizes cadmium-induced neurotoxicity by activating the transcription factor EB-dependent autophagy-lysosome machinery in mouse neuroblastoma cells.
AuthorsLi M, Pi H, Yang Z, Reiter RJ, Xu S, Chen X, Chen C, Zhang L, Yang M, Li Y, Guo P, Li G, Tu M, Tian L, Xie J, He M, Lu Y, Zhong M, Zhang Y, Yu Z, Zhou Z,
JournalJ Pineal Res
PubMed ID27396692
Cadmium (Cd), a highly ubiquitous heavy metal, induces neurotoxicity. Melatonin, a major secretory product of the pineal gland, protects against Cd-induced neurotoxicity. However, the mechanism that accounts for this protection remains to be elucidated. Herein, we exposed mouse neuroblastoma cells (Neuro-2a cells) to different concentrations of cadmium chloride (CdCl2 ) ... More
Trehalose, an mTOR-Independent Inducer of Autophagy, Inhibits Human Cytomegalovirus Infection in Multiple Cell Types.
AuthorsBelzile JP, Sabalza M, Craig M, Clark E, Morello CS, Spector DH
JournalJ Virol
PubMed ID26559848
Human cytomegalovirus (HCMV) is the major viral cause of birth defects and a serious problem in immunocompromised individuals and has been associated with atherosclerosis. Previous studies have shown that the induction of autophagy can inhibit the replication of several different types of DNA and RNA viruses. The goal of the ... More
Trigonelline prevents high cholesterol and high fat diet induced hepatic lipid accumulation and lipo-toxicity in C57BL/6J mice, via restoration of hepatic autophagy.
AuthorsSharma L, Lone NA, Knott RM, Hassan A, Abdullah T
JournalFood Chem Toxicol
PubMed ID30208301
Non-alcoholic fatty liver disease (NAFLD) is often linked with impaired hepatic autophagy. Here, we studied the alterations in hepatocellular autophagy by high cholesterol and high-fat diet (HC-HF) diet in C57BL/6J mice, and by palmitic acid (PA), in AML-12 and HepG2 cells. Further, we analysed role of Trigonelline (TG), a plant ... More
Andrographolide simultaneously augments Nrf2 antioxidant defense and facilitates autophagic flux blockade in cigarette smoke-exposed human bronchial epithelial cells.
AuthorsTan WSD, Liao W, Peh HY, Vila M, Dong J, Shen HM, Wong WSF
JournalToxicol Appl Pharmacol
PubMed ID30291937
Cigarette smoking is the leading cause of chronic obstructive pulmonary disease (COPD). Cigarette smoke heightens oxidative stress and impairs autophagy, advancing COPD progression. Andrographolide is a bioactive diterpenoid lactone isolated from the plant Andrographis paniculata which has been a traditional medicinal herb for respiratory diseases. As airway epithelial cells form ... More
Therapeutic potential of monoterpene a-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro.
AuthorsPudelek M, Catapano J, Kochanowski P, Mrowiec K, Janik-Olchawa N, Czyz J, Ryszawy D
JournalFitoterapia
PubMed ID30825580
Thuja occidentalis L. is indigenous for Northern America and commonly cultivated in Europe. Raw materials obtained from this tree are widely applied in the ethnomedicine and phytotherapy of numerous ailments, incl. scurvy, cystitis, rheumatism and cancer. Despite wide medicinal applications of Thuja occidentalis, still little is known on its therapeutic ... More
Identification of PIKfyve kinase as a target in multiple myeloma.
Authorsde Campos CB, Zhu YX, Sepetov N, Romanov S, Bruins LA, Shi CX, Stein CK, Petit JL, Polito AN, Sharik ME, Meermeier EW, Ahmann GJ, Armenta IDL, Kruse J, Bergsagel PL, Chesi M, Meurice N, Braggio E, Stewart AK
JournalHaematologica
PubMed ID31582538
The cellular cytotoxicity of APY0201, a PIKfyve inhibitor, against multiple myeloma was initially identified in an unbiased
Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction.
AuthorsRakshit J, Priyam A, Gowrishetty KK, Mishra S, Bandyopadhyay J
JournalJ Trace Elem Med Biol
PubMed ID31570251
Intracellular iron involves in Fenton's reaction-mediated Hydroxyl radical (OH·) generation by reacting with the neurotoxic agent 6-Hydroxydopamine (6-OHDA) autoxidation derivative Hydrogen Peroxide (H
Modulating EGFR-MTORC1-autophagy as a potential therapy for persistent fetal vasculature (PFV) disease.
AuthorsYazdankhah M, Shang P, Ghosh S, Bhutto IA, Stepicheva N, Grebe R, Hose S, Weiss J, Luo T, Mishra S, Riazuddin SA, Ghosh A, Handa JT, Lutty GA, Zigler JS, Sinha D
JournalAutophagy
PubMed ID31462148
Persistent fetal vasculature (PFV) is a human disease that results from failure of the fetal vasculature to regress normally. The regulatory mechanisms responsible for fetal vascular regression remain obscure, as does the underlying cause of regression failure. However, there are a few animal models that mimic the clinical manifestations of ... More