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Invitrogen
ALX4 Polyclonal Antibody
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Product Details
PA5-113457
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant Human Homeobox protein aristaless-like 4 protein (112-216AA)
Conjugate
Form
Liquid
Concentration
4.17 mg/mL
Amount
100 µg
Purification
Protein G
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.03% ProClin 300
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: aristaless 4; aristaless-like homeobox 4; Homeobox protein aristaless-like 4; homeodomain transcription factor ALX4
Gene Aliases: ALX4; CRS5; FND2; KIAA1788
UniProt ID: (Human) Q9H161
Entrez Gene ID: (Human) 60529, (Rat) 296511
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
protein binding
sequence-specific DNA binding
HMG box domain binding
sequence-specific double-stranded DNA binding
molecular_function
protein heterodimerization activity
homeodomain transcription factor
skeletal system development
hair follicle development
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
pattern specification process
muscle organ development
post-embryonic development
anterior/posterior pattern specification
limb morphogenesis
embryonic forelimb morphogenesis
embryonic hindlimb morphogenesis
embryonic digit morphogenesis
regulation of apoptotic process
positive regulation of transcription from RNA polymerase II promoter
animal organ development
digestive tract development
neuron development
embryonic skeletal system morphogenesis
skeletal system morphogenesis
palate development
transcription from RNA polymerase II promoter
biological_process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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