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Invitrogen
RNF7 Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
PA5-19233
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide sequence (DACLRCQAENKQE) corresponding to the internal amino acids of RNF7 (aa 59-72).
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Amount
100 µg
Purification
Ammonium sulfate precipitation
Storage buffer
TBS, pH 7.3, with 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
This antibody is predicted to react with mouse based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 8,000.
Target Information
The protein encoded by this gene is a highly conserved ring finger protein. It is an essential subunit of SKP1-cullin/CDC53-F box protein ubiquitin ligases, which are a part of the protein degradation machinery important for cell cycle progression and signal transduction. This protein interacts with, and is a substrate of, casein kinase II (CSNK2A1/CKII). The phosphorylation of this protein by CSNK2A1 has been shown to promote the degradation of IkappaBalpha (CHUK/IKK-alpha/IKBKA) and p27Kip1(CDKN1B). Alternatively spliced transcript variants encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CKII beta-binding protein 1; OTTHUMP00000180645; regulator of cullins 2; SAG; SAG-v; sensitive to apoptosis gene protein; sensitive to apoptosis zinc RING finger protein SAG; sensitive to apoptosis, zinc RING finger protein SAG, regulator of cullins 2; unnamed protein product; zinc RING finger protein SAG
Gene Aliases: CKBBP1; rbx2; ROC2; SAG
UniProt ID: (Human) Q9UBF6
Entrez Gene ID: (Human) 9616
ubiquitin-dependent protein catabolic process
protein ubiquitination
positive regulation of cell migration
endoplasmic reticulum unfolded protein response
intracellular signal transduction
reelin-mediated signaling pathway
proteasome-mediated ubiquitin-dependent protein catabolic process
post-translational protein modification
protein neddylation
response to redox state
negative regulation of focal adhesion assembly
protein K11-linked ubiquitination
negative regulation of focal adhesion disassembly
regulation of neuron migration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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