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Invitrogen
Phospho-Cardiac Troponin I (Thr142) Polyclonal Antibody
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FIGURE: 1 / 1
Phospho-Cardiac Troponin I (Thr142) Antibody (PA5-35713) in WB
Western blot analysis of Phospho-Cardiac Troponin I pThr142 in mouse heart tissue lysates with a blocking peptide (lane 1) and no blocking peptide (lane 2) using a Phospho-Cardiac Troponin I pThr142 polyclonal antibody (Product # PA5-35713).
Product Details
PA5-35713
Product Specifications
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide derived from human TNNI3 around the phosphorylation site of Threonine 142
Conjugate
Form
Liquid
Concentration
Lot-Specific
Storage conditions
-20°C
Shipping conditions
Ambient
RRID
Product Specific Information
Concentration is lot-specific and will vary from 0.5-0.6 mg/ml
Target Information
Cardiac Troponin I (Cardiac-specific troponin I, TnI, Troponin I) is an integral inhibitory protein in cardiac muscle that exists as part of a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit of troponin binds to tropomyosin-t form, a troponin-tropomyosin complex, anchored in place by the binding of TnI to actin, within muscle thin filaments. Structural change resulting from the binding of calcium to specific sites on the regulatory TnC subunit, releases the inhibitory region of TnI from actin, anabling the attachment of the molecular motor protein myosin, allowing for muscle contraction and hence movement. The measurements of blood TnI and TnT levels is an important diagnostics indicator of heart muscle damage, and can be used to differentiate between angina and myocardial infarction in patients with chest pains. Cardiac Troponin I has also been shown to inhibit angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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