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Invitrogen
AKR1C3 Polyclonal Antibody
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Product Details
PA5-95926
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-323 of human AKR1C3 (NP_0037304)
Conjugate
Form
Liquid
Concentration
0.6 mg/mL
Amount
60 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.05% ProClin 300
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Immunogen sequence: MDSKHQCVKL NDGHFMPVLG FGTYAPPEVP RSKALEVTKL AIEAGFRHID SAHLYNNEEQ VGLAIRSKIA DGSVKREDIF YTSKLWSTFH RPELVRPALE NSLKKAQLDY VDLYLIHSPM SLKPGEELSP TDENGKVIFD IVDLCTTWEA MEKCKDAGLA KSIGVSNFNR RQLEMILNKP GLKYKPVCNQ VECHPYFNRS KLLDFCKSKD IVLVAYSALG SQRDKRWVDP NSPVLLEDPV LCALAKKHKR TPALIALRYQ LQRGVVVLAK SYNEQRIRQN VQVFEFQLTA EDMKAIDGLD RNLHYFNSDS FASHPNYPYS DEY; Positive Samples: U-87MG, 293T, LO2, A-549, DU145, Mouse kidney; Cellular Location: Cytoplasm
Target Information
AKR1C3 a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-beta-HSD 5; 17-beta-hydroxysteroid dehydrogenase type 5; 17beta-HSD5; 2-dih; 3-alpha hydroxysteroid dehydrogenase, type II; 3-alpha-HSD type 2; 3-alpha-HSD type II, brain; 3-alpha-hydroxysteroid dehydrogenase type 2; Aldo-keto reductase family 1 member C3; chlordecone reductase homolog; Chlordecone reductase homolog HAKRb; DD-3; dihydrodiol dehydrogenase; Dihydrodiol dehydrogenase 3; Dihydrodiol dehydrogenase type I; dihydrodiol dehydrogenase X; HA1753; HSD; indanol dehydrogenase; KIAA0119; PGFS; Prostaglandin F synthase; Testosterone 17-beta-dehydrogenase 5; trans-1,2-dihydrobenzene-1,2-diol dehydrogenase; type IIb 3-alpha hydroxysteroid dehydrogenase; unnamed protein product
Gene Aliases: AKR1C3; DD3; DDH1; DDX; HA1753; HAKRB; HAKRe; hluPGFS; HSD17B5; KIAA0119; PGFS
UniProt ID: (Human) P42330
Entrez Gene ID: (Human) 8644
retinal dehydrogenase activity
alditol:NADP+ 1-oxidoreductase activity
estradiol 17-beta-dehydrogenase activity
retinol dehydrogenase activity
protein binding
alcohol dehydrogenase (NADP+) activity
oxidoreductase activity
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
testosterone dehydrogenase [NAD(P)] activity
bile acid binding
prostaglandin H2 endoperoxidase reductase activity
prostaglandin D2 11-ketoreductase activity
geranylgeranyl reductase activity
ketoreductase activity
prostaglandin-F synthase activity
15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity
androsterone dehydrogenase activity
5-alpha-androstane-3-beta,17-beta-diol dehydrogenase (NADP+) activity
testosterone dehydrogenase (NAD+) activity
androstan-3-alpha,17-beta-diol dehydrogenase activity
testosterone 17-beta-dehydrogenase (NADP+) activity
ketosteroid monooxygenase activity
delta4-3-oxosteroid 5beta-reductase activity
NADP-retinol dehydrogenase activity
retinoid metabolic process
alcohol metabolic process
lipid metabolic process
prostaglandin metabolic process
G-protein coupled receptor signaling pathway
response to nutrient
steroid metabolic process
positive regulation of cell proliferation
male gonad development
cellular response to starvation
farnesol catabolic process
keratinocyte differentiation
monocarboxylic acid metabolic process
hormone metabolic process
progesterone metabolic process
retinol metabolic process
retinal metabolic process
macromolecule metabolic process
daunorubicin metabolic process
doxorubicin metabolic process
prostanoid biosynthetic process
regulation of retinoic acid receptor signaling pathway
positive regulation of protein kinase B signaling
testosterone biosynthetic process
renal absorption
cellular response to calcium ion
cellular response to prostaglandin stimulus
cellular response to corticosteroid stimulus
cellular response to jasmonic acid stimulus
cellular response to prostaglandin D stimulus
negative regulation of retinoic acid biosynthetic process
regulation of testosterone biosynthetic process
positive regulation of endothelial cell apoptotic process
positive regulation of reactive oxygen species metabolic process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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