Thermo Scientific™

Pierce™ Premium Grade SPDP

Catalog number:  PG82088

 Related applications: Protein Labeling & Crosslinking

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Thermo Scientific™ Pierce™ Premium Grade SPDP is our highest quality formulation of this pyridyldithiol-based amine-to-sulfhydryl crosslinker, specially characterized for applications where product integrity and risk minimization are paramount. SPDP is a disulfide crosslinker used for reversible (reducible) amine-to-sulfhydryl conjugation.

• High quality—identity and purity confirmed by multiple tests, including quantitative NMR
• Product integrity—enhanced level of testing and characterization compared to standard grade
• Lot retention—ample supply of past lots retained to help ensure future process testing
• Change management—Change Control Notification (CCN) service
• Consistent manufacture—batch-specific manufacturing documentation review

Compared to the standard grade product, Premium Grade SPDP provides more clearly defined quality and product support by including increased analytical testing and product characterization, greater batch-specific information and quality assurance review, extensive lot sample retention, and change control notification.

SPDP is N-succinimidyl 3-(2-pyridyldithio)-propionate, a crosslinker for amine-to-sulfhydryl conjugation that forms cleavable (reducible) disulfide bonds with cysteine sulfhydryls. At one end is an N-hydroxysuccinimide (NHS) ester that will react with a primary amine to form a stable amide bond. At the other end is a pyridyl disulfide group that will react with a sulfhydryl group to form a reversible disulfide bond.
For Research Use Only. Not for use in diagnostic procedures.


Crosslinker Type: Heterobifunctional
Labeling Method: Chemical Labeling
Product Line: Pierce™
Product Size: 1 g
Solubility: DMF (Dimethylformamide), DMSO (Dimethylsulfoxide)
Spacer: Cleavable, Short

Contents & storage

Premium Grade succinimidyl 3-(2-pyridyldithio)propionate powder.
Store with desiccant at -20°C.
Sufficient for 3.20 L of typical 1X (1 mM) reaction solution or for ~500 uses at 2 mg reagent per use.


Manuals & protocols