Fluorescein-Poly GAT

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Description

A general fluorescein peptide substrate consisting of a polymer of glutamate, alanine, and tyrosine that is used to monitor tyrosine kinase activity.

For use in combination with the LanthaScreen® Tb-pY20 Antibody (PV3552) to evaluate inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Amino Acid Sequence: Fluorescein- Poly Glu:Ala:Tyr (6:3:1)
Detection Method: Fluorescent
Label or Dye: FITC (Fluorescein)
Product Size: 1 mL
Research Category: Signal Transduction
Shipping Condition: Dry Ice
Substrate: Fluorescein-Poly GAT
Substrate Properties: Peptide-Based Substrate
Substrate Type: Kinase Substrate
Target Enzyme: Tyrosine Kinases
Validated Kinases: ABL1, ABL2, AXL, BLK, BMX, BTK, CSF1R, CSK, DDR2, EGFR, EPHA1, EPHA2, EPHA3, EPHA4, EPHA5, EPHA7, EPHA8, EPHB1, EPHB2, EPHB3, EPHB4, ERBB2, ERBB4, FER, FGFR1, FGFR2, FGFR3, FGFR4, FGR, FLT1, FLT3, FLT4, FRK, FYN, HCK, IGF1R, INSR, KDR, KIT, LCK, LTK, LYNA, LYNB, MATK, MERTK, MET, MST1R, MUSK, NTRK1, NTRK2, NTRK3, PDGFRA, PDGFRB, PTK2, PTK2B, PTK6, RET, ROS1, SRC, SRCN1, SRMS, SYK, TEC, TEK, TNK2, TTK, TYRO3, YES1, ZAP70

Contents & storage

30 µM Fluorescein Poly-GAT peptide substrate in 10 mM HEPES (pH 7.5), 137 mM NaCl, and 2.7 mM KCl (HEPES buffered saline). Store at -20°C.