The alpha subunit of Eukaryotic initiation factor 2 (eIF2alpha) plays a key regulatory role in protein synthesis. In response to a cellular stress, phosphorylation of eIF2alpha at Ser52 occurs by the EIF2AK family of kinases including PERK (EIF2AK3) and PKR (EIF2AK2) to prohibit the initiation of protein synthesis.
For use in combination with the GFP-EIF2alpha physiological protein substrate (PV4809) to evaluate inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.
Biochemical Kinase Assays
GFP (EmGFP), Tb (Terbium)
Primary or Secondary
Gene ID (Entrez)
Antibody Molecular Weight
Lanthanide Chelates, Terbium (Tb)
Biochemical terbium phospho-specific activity
Label or Dye
Tb (Terbium), GFP (EmGFP)
EIF2AK1, EIF2AK2, EIF2AK3
Contents & Storage
Terbium-labeled anti-eIF2alpha [pSer52] antibody in HEPES buffered saline. Store at -20°C.