A phospho specific antibody directed to the ezrin⁄radixin⁄moesin (ERM) peptide that is a substrate for LRRK2 (Leucine-rich repeat kinase 2) and LRRK2 mutants. Mutations in LRRK2 have been found to be related to late-onset Parkinson's disease. For use in combination with the Fluorescein-ERM (LRRKtide) substrate (PV4901) to evaluate inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.
Specifications
Conjugate
Tb (Terbium)/Lanthanide Chelates
Quantity
25 μg
Excitation/Emission
340⁄490, 520
Reactivity
Human
Shipping Condition
Dry Ice
Readout
End Point
Reactivity abrv
Hu
Target Gene
Ser/Thr Kinases
Product Line
LanthaScreen™
Contents & Storage
Terbium-labeled pERM (pLRRKtide) antibody in HEPES buffered saline. Store at -20°C.