Thermo Scientific™

LanthaScreen™ Tb-pERM (pLRRKtide) Antibody Kit

Catalog number:  PV4899

Related applications:

Protein Assays and Analysis

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Description

A phospho specific antibody directed to the ezrin/radixin/moesin (ERM) peptide that is a substrate for LRRK2 (Leucine-rich repeat kinase 2) and LRRK2 mutants. Mutations in LRRK2 have been found to be related to late-onset Parkinson's disease.

For use in combination with the Fluorescein-ERM (LRRKtide) substrate (PV4901) to evaluate inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Antibody Conjugate: Lanthanide Chelates, Terbium (Tb)
Antibody Molecular Weight: 150000 Da
Assay Entry: Biochemical terbium phospho-specific activity
Excitation/Emission: 340⁄490, 520
Label Type: Lanthanide Chelates
Label or Dye: Tb (Terbium), FITC (Fluorescein)
Product Line: LanthaScreen®
Reactivity: Human
Reactivity abrv: Hu
Readout: End Point
Shipping Condition: Dry Ice
Target Entry: LRRK2 D1994A, LRRK2 R1441C, LRRK2 I2020T, LRRK2 G2019S, LRRK2
Target Enzyme: Serine⁄Threonine Kinases
Technique: TR-FRET
Validated Kinases: LRRK2
Format: 384-well plate
Gene ID (Entrez): 120892

Contents & storage

Terbium-labeled anti-ERM [pLRRKtide] antibody in HEPES buffered saline. Store at -20°C.