Fluorescein-ERM (LRRKtide)

Catalog number:  PV4901

Related applications:

Protein Assays and Analysis

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Description

A fluorescein-labeled peptide substrate based upon ezrin/radixin/moesin (ERM) that is phosphorylated by LRRK2 and LRRK2 mutants.

For use in combination with the LanthaScreen® Tb-anti-ERM (pLRRKtide) Antibody (PV4899) to evalute inhibitors in medium to high throughput screening applications.
For Research Use Only. Not for use in diagnostic procedures.

Specifications

Amino Acid Sequence: Fluorescein-GAGRLGRDKYKTLRQIRQ
Assay Entry: Biochemical terbium phospho-specific activity
Detection Method: Fluorescent
Gene ID (Entrez): 120892
Label or Dye: FITC (Fluorescein)
Shipping Condition: Dry Ice
Substrate: ERM (LRRKtide)
Substrate Properties: Peptide-Based Substrate
Target Entry: LRRK2 D1994A, LRRK2 R1441C, LRRK2 I2020T, LRRK2 G2019S, LRRK2
Target Enzyme: Serine⁄Threonine Kinases
Validated Kinases: LRRK2
Substrate Type: Kinase Substrate
Molecular Weight: 2475.8 Da

Contents & storage

400 µM Fluorescein-ERM (LRRKtide) peptide substrate in water. Store at -20°C and protect from light.