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Thermo Scientific™

TheraPure™ GMP Nucleotides

Name: TheraPure™ GMP Nucleotides
SKU: R00014SKB002
Price: 2,160.00 USD

Catalog number: R00014SKB002

Related applications: In Vitro Transcription

Thermo Scientific™

TheraPure™ GMP Nucleotides

Catalog number: R00014SKB002

Related applications: In Vitro Transcription

Thermo Scientific TheraPure GMP nucleoside triphosphates (NTPs) are manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. They are suitable as core building blocks for mRNA synthesis in the development and manufacturing of mRNA therapeutics. Nucleotides ATP, CTP, GTP, and UTP are available and are supplied in sodium- or Tris-titrated solutions.

Catalog Number

R00014SKB002

Unit Size

Each

Product Type

ATP, tris solution

Concentration

200 mM

Quantity

5 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	5 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R00014SKB005

Unit Size

Each

Product Type

ATP, tris solution

Concentration

200 mM

Quantity

50 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	50 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R00014SKB004

Unit Size

Each

Product Type

ATP, tris solution

Concentration

200 mM

Quantity

500 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	500 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R044SKB001

Unit Size

Each

Product Type

ATP, sodium solution

Concentration

100 mM

Quantity

3.5 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	3.5 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R044SKB002

Unit Size

Each

Product Type

ATP, sodium solution

Concentration

100 mM

Quantity

17 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	17 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R0441SKB003

Unit Size

Each

Product Type

ATP, sodium solution

Concentration

100 mM

Quantity

50 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	50 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R0441SKB009

Unit Size

Each

Product Type

ATP, sodium solution

Concentration

100 mM

Quantity

500 mL

Format

Business supply

Price (USD)

Request A Quote

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	500 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R00015SKB002

Unit Size

Each

Product Type

CTP, tris solution

Concentration

200 mM

Quantity

5 mL

Format

Business supply

Price (USD)

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	483.16 g/mol
Product Type	CTP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	5 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R00015SKB005

Unit Size

Each

Product Type

CTP, tris solution

Concentration

200 mM

Quantity

50 mL

Format

Business supply

Price (USD)

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	483.16 g/mol
Product Type	CTP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	50 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Catalog Number

R00015SKB004

Unit Size

Each

Product Type

CTP, tris solution

Concentration

200 mM

Quantity

500 mL

Format

Business supply

Price (USD)

Availability

Full specifications

Quantity

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	483.16 g/mol
Product Type	CTP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	500 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Showing 10 of 36Show more

Catalog Number Specifications Unit Size Product Type Concentration Quantity Format Price (USD) Availability Quantity

R00014SKB002

Full specifications

Each

ATP, tris solution

200 mM

5 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	5 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R00014SKB005

Full specifications

Each

ATP, tris solution

200 mM

50 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	50 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R00014SKB004

Full specifications

Each

ATP, tris solution

200 mM

500 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	500 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R044SKB001

Full specifications

Each

ATP, sodium solution

100 mM

3.5 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	3.5 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R044SKB002

Full specifications

Each

ATP, sodium solution

100 mM

17 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	17 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R0441SKB003

Full specifications

Each

ATP, sodium solution

100 mM

50 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	50 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R0441SKB009

Full specifications

Each

ATP, sodium solution

100 mM

500 mL

Business supply

Request A Quote

Format	Business supply
pH	7.3 to 7.5
Molecular Weight (g/mol)	507.18 g/mol
Product Type	ATP, sodium solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	100 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	500 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R00015SKB002

Full specifications

Each

CTP, tris solution

200 mM

5 mL

Business supply

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	483.16 g/mol
Product Type	CTP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	5 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R00015SKB005

Full specifications

Each

CTP, tris solution

200 mM

50 mL

Business supply

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	483.16 g/mol
Product Type	CTP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	50 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

R00015SKB004

Full specifications

Each

CTP, tris solution

200 mM

500 mL

Business supply

Format	Business supply
pH	7.3 to 7.7
Molecular Weight (g/mol)	483.16 g/mol
Product Type	CTP, tris solution
Shelf Life	Up to 36 months after manufacturing when stored at –20°C
Concentration	200 mM
Label or Dye	Unlabeled
Purity	≥99%
Quantity	500 mL
Product Line	TheraPure™ GMP
Color	Transparent
For Use With (Application)	IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit Size	Each

Showing 10 of 36Show more

Thermo Scientific TheraPure GMP* nucleoside triphosphates (NTPs) are manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. They are suitable as core building blocks for mRNA synthesis in the development and manufacturing of mRNA therapeutics. Nucleotides ATP, CTP, GTP, and UTP are available and are supplied in sodium- or Tris-titrated solutions.

Designed for process development and manufacturing

TheraPure GMP nucleotides help accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization by providing:

Quality—meet critical product quality needs to accelerate therapeutic development and manufacture
Minimal risk—reduce risks in developing a therapeutic by utilizing proven products
Technical partnership—partner with expert product and technical support
Secure and consistent supply—count on a secure and stable supply of product at a global scale

Supported by unique quality system

TheraPure GMP nucleotides are supported by a comprehensive quality system and documentation, including:

Manufactured to relevant ICH Q7 GMP guidelines
Animal-origin–free (AOF) manufacturing processes, materials, and facilities
Validated manufacturing processes and analytical test methods
Comprehensive impurity profiles
Verified compendial assays where applicable
Product stability data
Tested by analytical methods following ICH Q2 guidelines whenever possible
Drug master file (DMF)

Two available formats

These two formats are offered to accommodate different mRNA manufacturing processes:

100 mM aqueous solution with Na+ titrated to pH 7.3–7.5 with NaOH
200 mM aqueous solution with Tris counterion titrated to pH 7.3–7.7 with Tris base

Modified nucleotides

TheraPure GMP N1-methylpseudo-UTP is also available.

*TheraPure GMP refers to the quality level of the raw, ancillary, or starting materials to be used for further manufacturing. TheraPure GMP products are manufactured in facilities with ISO 9001–certified quality management systems that operate in accordance with relevant good manufacturing practice (GMP) principles, as outlined in ICH Q7 or equivalent guidance documents or standards.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.

TheraPure™ GMP Nucleotides

TheraPure™ GMP Nucleotides

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Citations & References