Differentiation of vancomycin resistant E. faecium
from E. faecalis
is achieved through the inclusion of two chromogens that are targeted by specific enzymes: phosphatase and α-galactosidase. The action of these enzymes on the chromogens results in a build-up of color within the colony. The color produced depends on which enzymes the organisms possess. The presence of phosphatase enzymes in both E. faecium
and E. faecalis
results in a light blue colony; however, E. faecium
also produces α-galactosidase resulting in a mix of blue and pink chromophores within the bacterium, producing indigo to purple colonies which are easily distinguished from the light blue E. faecalis
Additional antibiotics, in combination with vancomycin, are present to suppress the growth of competing flora including E. gallinarum
and E. casseliflavus
, both of which are intrinsically resistant to vancomycin, possessing the chromosomally encoded VanC resistance mechanism. The VanC resistance mechanism is not readily transmissible between organisms and, as such, is deemed less clinically significant than VanA and VanB mechanisms which are encoded on freely transmissible genetic elements, plasmids and transposons, thus increasing the risk of resistance genes spreading to other organisms.
- Rapidly and economically detects colonization of Vancomycin-Resistant Enterococcus (VRE) colonization
- Aids in the prevention and controls the spread of vancomycin resistance in healthcare settings
- Correctly classifies patients whether positive or negative
- Provides superior results in a selective and differential chromogenic medium
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