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Thermo Scientific™

TheraPure™ GMP Nucleotides

Catalog number: R044SKB002
Have Questions?
Thermo Scientific™

TheraPure™ GMP Nucleotides

Catalog number: R044SKB002
Have Questions?
Thermo Scientific TheraPure GMP nucleoside triphosphates (NTPs) are manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. They are suitable as core building blocks for mRNA synthesis in the development and manufacturing of mRNA therapeutics. Nucleotides ATP, CTP, GTP, and UTP are available and are supplied in sodium- or Tris-titrated solutions.
 
Catalog Number
R044SKB002
Unit Size
Each
Product Type
ATP, sodium solution
Concentration
100 mM
Quantity
17 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity17 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
ATP, tris solution
Concentration
200 mM
Quantity
5 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity5 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
ATP, tris solution
Concentration
200 mM
Quantity
50 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity50 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
ATP, tris solution
Concentration
200 mM
Quantity
500 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity500 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
ATP, sodium solution
Concentration
100 mM
Quantity
3.5 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity3.5 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
ATP, sodium solution
Concentration
100 mM
Quantity
50 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity50 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
ATP, sodium solution
Concentration
100 mM
Quantity
500 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity500 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
CTP, tris solution
Concentration
200 mM
Quantity
5 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)483.16 g/mol
Product TypeCTP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity5 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
CTP, tris solution
Concentration
200 mM
Quantity
50 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)483.16 g/mol
Product TypeCTP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity50 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Catalog Number
Unit Size
Each
Product Type
CTP, tris solution
Concentration
200 mM
Quantity
500 mL
Format
Business supply
Price (USD)
Availability
-
Full specifications
Quantity
-
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)483.16 g/mol
Product TypeCTP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity500 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Showing 10 of 36Show more
Catalog NumberSpecificationsUnit SizeProduct TypeConcentrationQuantityFormatPrice (USD)AvailabilityQuantity
R044SKB002Full specifications
Each ATP, sodium solution100 mM17 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity17 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R00014SKB002Full specifications
Each ATP, tris solution200 mM5 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity5 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R00014SKB005Full specifications
Each ATP, tris solution200 mM50 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity50 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R00014SKB004Full specifications
Each ATP, tris solution200 mM500 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity500 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R044SKB001Full specifications
Each ATP, sodium solution100 mM3.5 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity3.5 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R0441SKB003Full specifications
Each ATP, sodium solution100 mM50 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity50 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R0441SKB009Full specifications
Each ATP, sodium solution100 mM500 mLBusiness supplyRequest A Quote--
FormatBusiness supply
pH7.3 to 7.5
Molecular Weight (g/mol)507.18 g/mol
Product TypeATP, sodium solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration100 mM
Label or DyeUnlabeled
Purity≥99%
Quantity500 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R00015SKB002Full specifications
Each CTP, tris solution200 mM5 mLBusiness supply
--
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)483.16 g/mol
Product TypeCTP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity5 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R00015SKB005Full specifications
Each CTP, tris solution200 mM50 mLBusiness supply
--
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)483.16 g/mol
Product TypeCTP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity50 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
R00015SKB004Full specifications
Each CTP, tris solution200 mM500 mLBusiness supply
--
FormatBusiness supply
pH7.3 to 7.7
Molecular Weight (g/mol)483.16 g/mol
Product TypeCTP, tris solution
Shelf LifeUp to 36 months after manufacturing when stored at –20°C
Concentration200 mM
Label or DyeUnlabeled
Purity≥99%
Quantity500 mL
Product LineTheraPure™ GMP
ColorTransparent
For Use With (Application)IVT Transcription, RNA Synthesis, mRNA Synthesis
Unit SizeEach
Showing 10 of 36Show more

Thermo Scientific TheraPure GMP* nucleoside triphosphates (NTPs) are manufactured to ICH Q7 GMP principles and supported by a comprehensive documentation package. They are suitable as core building blocks for mRNA synthesis in the development and manufacturing of mRNA therapeutics. Nucleotides ATP, CTP, GTP, and UTP are available and are supplied in sodium- or Tris-titrated solutions.

Designed for process development and manufacturing

TheraPure GMP nucleotides help accelerate mRNA vaccine and therapeutics production from preclinical development to commercialization by providing:

  • Quality—meet critical product quality needs to accelerate therapeutic development and manufacture
  • Minimal risk—reduce risks in developing a therapeutic by utilizing proven products
  • Technical partnership—partner with expert product and technical support
  • Secure and consistent supply—count on a secure and stable supply of product at a global scale

Supported by unique quality system

TheraPure GMP nucleotides are supported by a comprehensive quality system and documentation, including:

  • Manufactured to relevant ICH Q7 GMP guidelines
  • Animal-origin–free (AOF) manufacturing processes, materials, and facilities
  • Validated manufacturing processes and analytical test methods
  • Comprehensive impurity profiles
  • Verified compendial assays where applicable
  • Product stability data
  • Tested by analytical methods following ICH Q2 guidelines whenever possible
  • Drug master file (DMF)

Two available formats

These two formats are offered to accommodate different mRNA manufacturing processes:

  • 100 mM aqueous solution with Na+ titrated to pH 7.3–7.5 with NaOH
  • 200 mM aqueous solution with Tris counterion titrated to pH 7.3–7.7 with Tris base

Modified nucleotides

TheraPure GMP N1-methylpseudo-UTP is also available.

*TheraPure GMP refers to the quality level of the raw, ancillary, or starting materials to be used for further manufacturing. TheraPure GMP products are manufactured in facilities with ISO 9001–certified quality management systems that operate in accordance with relevant good manufacturing practice (GMP) principles, as outlined in ICH Q7 or equivalent guidance documents or standards.

For Research Use or Further Manufacturing. Not for diagnostic use or direct administration into humans or animals.

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