NFκ B/p65 (Rel A), Rabbit Polyclonal Antibody

Thermo Scientific™  Related applications: Anatomical Pathology

Take advantage of a quality product that delivers accurate results with the Thermo Scientific™ NFκB/p65 (Rel A), Rabbit Polyclonal Antibody.

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Description

NFκB is a heterodimer consisting of a 50kDa DNA binding subunit and a 65kDa transactivating subunit (RelA). The p50/p65 heterodimer is present in the cytoplasm in inactive form bound to its inhibitor, IκB. In unstimulated cells, nuclear localization signals present on p65 are masked by members of the IκB family of inhibitory proteins. Subsequent to cell stimulation, IκB undergoes phosphorylation, ubiquitination and degradation by a proteosome-dependent pathway, allowing nuclear translocation of the active dimeric NFκB transcription factor.

Host Species: Rabbit

Isotype: IgG

Species Reactivity: Human, Rat and Rabbit. Others not tested.

Epitope: Internal domain

Immunogen: A synthetic peptide corresponding to internal domain of human NFκB/p65

Molecular Weight: 65kDa

Positive Control: Prostate gland and placenta

Cellular Localization: Cytoplasmic

Recommended for:

  • Immunohistochemistry (Formalin/paraffin)
  • Western Blotting

Note:

USA: RUO; Int'l: RUO



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