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Invitrogen
Human COP1 (aa 173-197) Control Fragment Recombinant Protein
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Product Details
RP-101616
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LHKGSLYPRIPGLGKELQTGTHKLS
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (48%), Rat (48%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62890. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Caspase inhibitor. Acts as a regulator of procaspase-1/CASP1 activation implicated in the regulation of the proteolytic maturation of pro-interleukin-1 beta (IL1B) and its release during inflammation. Inhibits the release of IL1B in response to LPS in monocytes. Also induces NF-kappa-B activation during the pro-inflammatory cytokine response. Also able to inhibit CASP1-mediated neuronal cell death, TNF-alpha, hypoxia-, UV-, and staurosporine-mediated cell death but not ER stress-mediated cell death. Acts by preventing activation of caspases CASP1 and CASP4, possibly by preventing the interaction between CASP1 and RIPK2. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CARD only domain-containing protein 1; CARD only protein; CARD-only protein 1; Caspase recruitment domain-containing protein 16; Caspase recruitment domain-only protein 1; caspase-1 dominant-negative inhibitor pseudo-ICE; Caspase-1 inhibitor COP; Pseudo interleukin-1 beta converting enzyme; pseudo interleukin-1beta converting enzyme; Pseudo-ICE; pseudo-IL1B-converting enzyme; unnamed protein product
Gene Aliases: CARD16; COP; COP1; LLID-114769; PSEUDO-ICE
UniProt ID: (Human) Q5EG05
Entrez Gene ID: (Human) 114769
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