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Invitrogen
Human HSD17B3 Control Fragment Recombinant Protein
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Product Details
RP-103273
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
NVGILPNLLPSHFLNAPDEIQSLIHCNITSVVKMTQLILKHMESRQKGLIL
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (76%), Rat (76%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63356. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
This isoform of 17 beta-hydroxysteroid dehydrogenase is expressed predominantly in the testis and catalyzes the conversion of androstenedione to testosterone. It preferentially uses NADP as cofactor. Deficiency can result in male pseudohermaphroditism with gynecomastia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 17-beta-HSD 3; 17-beta-HSD3; 17-beta-hydroxysteroid dehydrogenase type 3; Estradiol 17-beta-dehydrogenase 2; HSD17B3; hydroxysteroid (17-beta) dehydrogenase 3 isoform HSD17B3_1; hydroxysteroid (17-beta) dehydrogenase 3 isoform HSD17B3_2; hydroxysteroid (17-beta) dehydrogenase 3 isoform HSD17B3_3; hydroxysteroid (17-beta) dehydrogenase 3 isoform HSD17B3_4; hydroxysteroid (17-beta) dehydrogenase 3 isoform HSD17B3_5; hydroxysteroid dehydrogenase 3; Short chain dehydrogenase/reductase family 12C member 2; Testicular 17-beta-hydroxysteroid dehydrogenase; Testosterone 17-beta-dehydrogenase 3
Gene Aliases: EDH17B3; HSD17B3; SDR12C2
UniProt ID: (Human) P37058
Entrez Gene ID: (Human) 3293
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