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Invitrogen
Human PLK5 (aa 2-67) Control Fragment Recombinant Protein
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Product Details
RP-97250
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
YTVLTGTPPFMASPLSEMYQNIREGHYPEPAHLSANARRLIVHLLAPNPAERPSLDHLLQDDFFTQ
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (82%), Rat (82%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-57120. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Polo-like kinase 5 (PLK5) is a member of the Polo-like kinase family, notable for its involvement in cell cycle regulation processes such as mitotic entry, spindle formation, and cytoplasmic division. PLK5 is distinguished from other family members by its low expression levels, particularly within different immunophenotypes, except for being notably elevated in the C5 subtype. Its expression has been linked to poor prognosis in non-small cell lung cancer, although this is not universally supported by all data sources, suggesting complex roles in tumor biology. In a mouse model, PLK5 functions as a DNA damage-inducible gene with nucleolar localization, facilitated by a specific nucleolus localization signal in its N-terminal. The protein's ectopic expression can lead to G1 phase arrest, indicating its role in cellular response to DNA damage. Research is ongoing to fully elucidate its function and prognostic implications across various cancer types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Inactive serine/threonine-protein kinase PLK5; PLK-5; Polo-like kinase 5; polo-like kinase 5, pseudogene
Gene Aliases: FG060302; PLK-5; PLK5; PLK5P; SgK384ps
UniProt ID: (Human) Q496M5
Entrez Gene ID: (Human) 126520
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