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Invitrogen
Human NTN3 (aa 40-120) Control Fragment Recombinant Protein
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Product Details
RP-98705
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
CVPGLVNAALGREVLASSTCGRPATRACDASDPRRAHSPALLTSPGGTASPLCWRSESLPRAPLNVTLTVPLGKAFELVFV
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
1M urea/PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (81%), Rat (81%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-62249. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
Netrin-3 (NTN3) is a gene located on chromosome 16q22.1, encoding a protein that belongs to the netrin family of secreted molecules crucial for axon guidance and cell signaling in nervous system development. NTN3 is primarily expressed in the central nervous system, where it functions as a guidance cue for developing neurons, influencing processes such as axon attraction or repulsion and the establishment of neural networks. The protein interacts with specific receptors on neuronal growth cones to mediate directional movement and synapse formation. Beyond its role in neural development, NTN3 is involved in tissue morphogenesis and cellular migration in other physiological contexts. Aberrant expression or mutations in NTN3 can lead to developmental disorders and neurodegenerative conditions due to impaired neural pathway formation. Research into NTN3 continues to explore its therapeutic potential for enhancing neural repair and regeneration in pathological states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Netrin-2, chicken, homolog of, like; Netrin-2-like protein; Netrin-3
Gene Aliases: NTN2L; NTN3
UniProt ID: (Human) O00634
Entrez Gene ID: (Human) 4917
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