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Invitrogen
Human CCDC114 (aa 331-420) Control Fragment Recombinant Protein
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Product Details
RP-98955
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
SKDDQHLLQEQQQKVLQQRMDKVHSEAERLEARFQDVRGQLEKLKADIQLLFTKAHCDSSMIDDLLGVKTSMGDRDMGLFLSLIEKRLVE
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (68%), Rat (68%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-60012. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The CCDC114 gene, located on chromosome 19, encodes a protein that is a key component of the structure and function of cilia, which are hair-like organelles present on the surface of many cell types. Structurally, CCDC114 belongs to the coiled-coil domain-containing family, which plays crucial roles in cellular organizations and motility. Functionally, CCDC114 is involved in forming the outer dynein arm of cilia, essential for their motility. Mutations in CCDC114 can lead to defects in ciliary structure, resulting in primary ciliary dyskinesia (PCD), a condition characterized by chronic respiratory tract infections, abnormal organ positioning, and other symptoms. Specifically, mutations like c.742G>A and c.584T>C have been identified to cause variant forms of PCD, as well as situs inversus, which is a complete mirror image reversal of the body's internal organ arrangement. Genetic investigations have shown that these mutations can significantly disrupt the function of cilia, confirming CCDC114's critical role in human ciliopathies.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: coiled-coil domain containing 114; Coiled-coil domain-containing protein 114; Outer dynein arm-docking complex subunit 1; unnamed protein product
Gene Aliases: CCDC114; CILD20; ODAD1
UniProt ID: (Human) Q96M63
Entrez Gene ID: (Human) 93233
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