ESE3 (Epithelial Specific ETS) belongs to a subgroup of related polypeptides within the ETS family of transcription factors. The members of the ESE group are expressed primarily in epithelial cells, and share a common structure with other subgroups within the family. ESE-3 is expressed in epithelial cells originating in a variety of tissues including trachea, salivary gland, esophagus, colon, prostate, seminal vesicle, breast, bladder, and uterus, among others. The expression of ESE-3 in trachea and colon appears to segregate mainly with epithelial cells of a secretory phenotype. In all cases, ESE3 expression appears to be restricted to differentiated epithelial cells. ESE-3 expression is consistently lost in carcinomas of various epithelial origins, including but not limited to, bladder, squamous carcinomas of stratified epithelia, breast ductal carcinoma, and cervical carcinoma.
Host Species: Rat
Species Reactivity: Human. Does not cross-react with mouse. Others not tested.
Immunogen: Purified His-tagged recombinant ESE-3 expressed in E. coli
Molecular Weight: 36 kDa
Positive Control: LnCAP
Cellular Localization: Nuclear staining
USA: RUO; Int'l: RUO
1. Tugores, A., et al. (2001) J. Biol. Chem., 276(23): 20397-20406