JC-1 Farbstoff (Mitochondrienmembranpotenzial-Sonde)

Zitierungen und Referenzen (400)

Invitrogen™

JC-1 Farbstoff (Mitochondrienmembranpotenzial-Sonde)

JC-1 ist ein neuartiger kationischer Carbocyanin-Farbstoff, der sich in Mitochondrien anreichert. Der Farbstoff liegt als Monomer in geringen Konzentrationen vorWeitere Informationen

Katalognummer	Menge
T3168	5 mg

Katalognummer T3168

Preis (EUR)

710,40

Sonderangebot

Exklusiv online

Endet: 15-Mar-2026

960,00

Ersparnis 249,60 (26%)

Zum Warenkorb hinzufügen

Menge:

Preis (EUR)

710,40

Sonderangebot

Exklusiv online

Endet: 15-Mar-2026

960,00

Ersparnis 249,60 (26%)

Zum Warenkorb hinzufügen

JC-1 ist ein neuartiger kationischer Carbocyanin-Farbstoff, der sich in Mitochondrien anreichert. Der Farbstoff liegt als Monomer in geringen Konzentrationen vor und erzeugt grüne Fluoreszenz, ähnlich der des Fluorescein. Bei höheren Konzentrationen bildet der Farbstoff J-Aggregate mit breitem Anregungsspektrum und einem Emissionsmaximum bei ∼590 nm. Diese Eigenschaften machen JC-1 zu einem empfindlichen Marker für das mitochondriale Membranpotenzial. JC-9 (D-22421) ist ein weiterer Farbstoff mit ähnlichen Eigenschaften.

Nur für Forschungszwecke. Nicht zur Verwendung bei diagnostischen Verfahren.

Specifications

NachweisverfahrenFluoreszent

Menge5 mg

VersandbedingungRaumtemperatur

Subzelluläre LokalisationMitochondrien

FarbeGrün

Zur Verwendung mit (Geräte)Fluoreszenzmikroskop, Durchflusszytometer

ProdukttypFarbstoff

Unit Size5 mg

Inhalt und Lagerung

Lagerung bei Raumtemperatur und vor Licht geschützt

Häufig gestellte Fragen (FAQ)

I am seeing high background outside of my neuronal cells when using membrane potential indicators. What can I do to reduce background?

If you use our FluoVolt Membrane Potential Kit (Cat. No. F10488), the kit provides a background suppressor to reduce this problem. For other indicators, consider the use of BackDrop Background Suppressor (Cat no. R37603, B10511, and B10512).

Find additional tips, troubleshooting help, and resources within our Cell Analysis Support Center.

What is the difference between fast and slow-response membrane potential probes?

Molecules that change their structure in response to the surrounding electric field can function as fast-response probes for the detection of transient (millisecond) potential changes. Slow-response dyes function by entering depolarized cells and binding to proteins or membranes. Increased depolarization results in additional dye influx and an increase in fluorescence, while hyperpolarization is indicated by a decrease in fluorescence. Fast-response probes are commonly used to image electrical activity from intact heart tissues or measure membrane potential changes in response to pharmacological stimuli. Slow-responding probes are often used to explore mitochondrial function and cell viability.

Find additional tips, troubleshooting help, and resources within our Cell Analysis Support Center.

What type of membrane potential indicators do you offer and how should I choose one for my experiment?

A membrane potential indicator selection guide can be found here (https://www.thermofisher.com/us/en/home/life-science/cell-analysis/cell-viability-and-regulation/ion-indicators/membrane-potential-indicators.html).

Find additional tips, troubleshooting help, and resources within our Cell Analysis Support Center.

Zitierungen und Referenzen (400)

Zitierungen und Referenzen

Abstract

Apoptosis induced by Rac GTPase correlates with induction of FasL and ceramides production.

Authors:Embade N,Valerón PF,Aznar S,López-Collazo E,Lacal JC

Journal:Molecular biology of the cell

PubMed ID:11102528

Rho proteins, members of the Ras superfamily of GTPases, are critical elements in signal transduction pathways governing cell proliferation and cell death. Different members of the family of human Rho GTPases, including RhoA, RhoC, and Rac1, participate in the regulation of apoptosis in response to cytokines and serum deprivation in ... More

Large-scale chemical dissection of mitochondrial function.

Authors:Wagner BK,Kitami T,Gilbert TJ,Peck D,Ramanathan A,Schreiber SL,Golub TR,Mootha VK

Journal:Nature biotechnology

PubMed ID:18297058

Mitochondrial oxidative phosphorylation (OXPHOS) is central to physiology and disease pathogenesis. To systematically investigate its activity and regulation, we performed a wide range of assays of OXPHOS physiology and nuclear and mitochondrial gene expression across 2490 chemical perturbations in muscle cells. Through mining of the resulting compendium, we discovered that: ... More

Authors:

Journal:

PubMed ID:10891486

Mitochondria--potential role in cell life and death.

Authors:Griffiths EJ

Journal:Cardiovascular research

PubMed ID:10727650

The mitochondrial death/life regulator in apoptosis and necrosis.

Authors:Kroemer G,Dallaporta B,Resche-Rigon M

Journal:Annual review of physiology

PubMed ID:9558479

Both physiological cell death (apoptosis) and, in some cases, accidental cell death (necrosis) involve a two-step process. At a first level, numerous physiological and some pathological stimuli trigger an increase in mitochondrial membrane permeability. The mitochondria release apoptogenic factors through the outer membrane and dissipate the electrochemical gradient of the ... More

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