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OriGene
EXD1 Monoclonal Antibody (OTI5B5), TrueMAB™
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Product Details
TA502098
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5B5
Immunogen
Full length human recombinant protein of human EXD1 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
0.58 mg/mL
Amount
58 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
EXD1 is an RNA-binding component of the PET complex, a multiprotein complex required for the processing of piRNAs during spermatogenesis. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposable elements, preventing their mobilization, which is essential for the germline integrity. The PET complex is required during the secondary piRNAs metabolic process for the PIWIL2 slicing-triggered loading of PIWIL4 piRNAs. In the PET complex, EXD1 probably acts as an RNA adapter. EXD1 is an inactive exonuclease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Exonuclease 3'-5' domain-containing protein 1; Exonuclease 3'-5' domain-like-containing protein 1; Inactive exonuclease EXD1; piRNA biogenesis protein EXD1; unnamed protein product
Gene Aliases: EXD1; EXDL1
UniProt ID: (Human) Q8NHP7
Entrez Gene ID: (Human) 161829
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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