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OriGene
MAPK13 Monoclonal Antibody (OTI2G1), TrueMAB™
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Product Details
TA505852
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Dog,
Human,
Mouse,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2G1
Immunogen
Full length human recombinant protein of human MAPK13 produced in HEK293T cell.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
MAPK13 (p38 delta) is a serine/threonine kinase that transduces a variety of extracellular signals, including cytokine and environmental stress responses. MAPK13 also regulates the differentiation of keratinocytes. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases, or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of SAPK4 encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MAP kinase 13; MAP kinase p38 delta; MAPK 13; MAPK13; mitogen activated protein kinase 13; Mitogen-activated protein kinase 13; Mitogen-activated protein kinase p38 delta; p38 delta MAP kinase; p38-delta MAPK; SAPK/Erk/kinase 4; SAPK4; Stress-activated protein kinase 4
Gene Aliases: MAPK 13; MAPK-13; MAPK13; p38delta; PRKM13; SAPK4; Serk4
UniProt ID: (Human) O15264, (Mouse) Q9Z1B7
Entrez Gene ID: (Human) 5603, (Dog) 612821, (Rat) 29513, (Mouse) 26415
nucleotide binding
protein kinase activity
protein serine/threonine kinase activity
MAP kinase activity
protein binding
ATP binding
kinase activity
transferase activity
protein serine kinase activity
transferase activity, transferring phosphorus-containing groups
non-receptor serine/threonine protein kinase
MAPK cascade
response to osmotic stress
positive regulation of interleukin-6 production
cellular response to stress
cellular response to UV
intracellular signal transduction
positive regulation of inflammatory response
stress-activated MAPK cascade
cellular response to hydrogen peroxide
cellular response to interleukin-1
cellular response to sorbitol
cellular response to anisomycin
cellular response to sodium arsenite
transcription, DNA-templated
regulation of transcription, DNA-templated
protein phosphorylation
peptidyl-serine phosphorylation
response to stress
cell cycle
phosphorylation
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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