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OriGene
RIPK3 Monoclonal Antibody (OTI2C11), TrueMAB™
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FIGURE: 1 / 1
RIPK3 Antibody (TA803101) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RIPK3 (RC209549, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RIPK3.
Product Details
TA803101
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI2C11
Immunogen
Human recombinant protein fragment corresponding to amino acids 233-518 of human RIPK3 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
RIPK3 is a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases, which contains a C-terminal domain unique from other RIP family members. RIPK3 is predominantly localized to the cytoplasm, and specifically, are colocalized in the mitochondrion which can undergo nucleocytoplasmic shuttling dependent on novel nuclear localization and export signals. RIPK3 is a component of the tumor necrosis factor (TNF) receptor-I signaling complex, and can induce apoptosis and weakly activate the NF-kappaB transcription factor and caspase-8 prevents RIPK3-dependent necrosis without inducing apoptosis by functioning in a proteolytically active complex with CFLAR and that this complex is required for the protective function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: receptor interacting protein 3; Receptor-interacting protein 3; Receptor-interacting serine/threonine-protein kinase 3; RIP-3; RIP-like protein kinase 3; Ser/Thr kinase; unnamed protein product
Gene Aliases: RIP3; RIPK3
UniProt ID: (Human) Q9Y572
Entrez Gene ID: (Human) 11035
regulation of T cell mediated cytotoxicity
regulation of adaptive immune response
apoptotic process
signal transduction
positive regulation of metabolic process
regulation of gene expression
programmed cell death
activation of protein kinase activity
regulation of interferon-gamma production
T cell differentiation in thymus
protein modification process
NIK/NF-kappaB signaling
regulation of apoptotic process
T cell homeostasis
positive regulation of transcription, DNA-templated
regulation of activated T cell proliferation
lymph node development
spleen development
thymus development
positive regulation of NF-kappaB transcription factor activity
defense response to virus
positive regulation of necroptotic process
regulation of activation-induced cell death of T cells
necroptotic process
cellular response to hydrogen peroxide
reactive oxygen species metabolic process
apoptotic signaling pathway
programmed necrotic cell death
necroptotic signaling pathway
execution phase of necroptosis
amyloid fibril formation
regulation of reactive oxygen species metabolic process
positive regulation of reactive oxygen species metabolic process
regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
positive regulation of intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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