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OriGene
NTRK1 Monoclonal Antibody (OTI5B6), TrueMAB™
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Product Details
TA806413
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5B6
Immunogen
Human recombinant protein fragment corresponding to amino acids 440-796 of human NTRK1 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
NTRK1 (TRKA) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. TrkA is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of TrkA leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in TrkA have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: DKFZp781I14186; EC 2.7.10.1; gp140trk; High affinity nerve growth factor receptor; kinase TrkA; Neurotrophic tyrosine kinase receptor type 1; neurotrophic tyrosine kinase, receptor, type 1; Oncogene TRK; p140-TrkA; trk tyrosine-specific protein kinase; Trk-A; TRK1-transforming tyrosine kinase protein; tropomyosin receptor kinase A; Tropomyosin-related kinase A; Tyrosine kinase receptor; Tyrosine kinase receptor A; unnamed protein product
Gene Aliases: MTC; NTRK1; p140-TrkA; TRK; Trk-A; TRK1; TRKA
UniProt ID: (Human) P04629
Entrez Gene ID: (Human) 4914
nucleotide binding
protein kinase activity
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
GPI-linked ephrin receptor activity
neurotrophin receptor activity
neurotrophin p75 receptor binding
protein binding
ATP binding
nerve growth factor receptor activity
kinase activity
transferase activity
kinase binding
identical protein binding
protein homodimerization activity
neurotrophin binding
nerve growth factor binding
protein phosphorylation
transmembrane receptor protein tyrosine kinase signaling pathway
spermatogenesis
nervous system development
axon guidance
learning or memory
circadian rhythm
negative regulation of cell proliferation
response to xenobiotic stimulus
programmed cell death involved in cell development
positive regulation of neuron projection development
peptidyl-tyrosine phosphorylation
olfactory nerve development
cell differentiation
B cell differentiation
neuron projection development
response to nutrient levels
response to nicotine
peptidyl-tyrosine autophosphorylation
nerve growth factor signaling pathway
mechanoreceptor differentiation
negative regulation of apoptotic process
positive regulation of programmed cell death
negative regulation of neuron apoptotic process
positive regulation of GTPase activity
positive regulation of angiogenesis
positive regulation of Ras protein signal transduction
protein autophosphorylation
neurotrophin TRK receptor signaling pathway
ephrin receptor signaling pathway
sympathetic nervous system development
neuron development
response to axon injury
detection of temperature stimulus involved in sensory perception of pain
detection of mechanical stimulus involved in sensory perception of pain
positive regulation of NF-kappaB transcription factor activity
neuron apoptotic process
response to hydrostatic pressure
response to electrical stimulus
positive regulation of protein kinase B signaling
positive regulation of synapse assembly
positive regulation of synaptic transmission, glutamatergic
Sertoli cell development
innervation
axonogenesis involved in innervation
behavioral response to formalin induced pain
positive regulation of ERK1 and ERK2 cascade
cellular response to nicotine
cellular response to growth factor stimulus
cellular response to beta-amyloid
cellular response to nerve growth factor stimulus
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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