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OriGene
TSEN15 Monoclonal Antibody (OTI5A3), TrueMAB™
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FIGURE: 1 / 2
TSEN15 Antibody (TA812717) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TSEN15 (RC205519, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TSEN1. Positive lysates LY409366 (100 µg) and LC409366 (20 µg) can be purchased separately from OriGene.
Product Details
TA812717
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
OTI5A3
Immunogen
Full length human recombinant protein of human TSEN15 produced in E.coli.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS with 1% BSA, 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: HsSEN15; SEN15 homolog; tRNA splicing endonuclease 15 homolog; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15; TSEN15 tRNA splicing endonuclease subunit; unnamed protein product
Gene Aliases: C1orf19; PCH2F; RGD1308584; SEN15; TSEN15
UniProt ID: (Human) Q8WW01
Entrez Gene ID: (Human) 116461, (Rat) 289083
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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