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Reliable 200 kV TEM/STEM imaging with automated workflows
The Thermo Scientific Talos F200C TEM delivers reliable performance with advanced automation in a versatile, multipurpose TEM/STEM platform designed for applications across the life and materials sciences.
Operating at 200 kV with a high-brightness X-FEG source, it provides high resolution and strong penetration capability. The constant-power C-TWIN lens supports enhanced TEM contrast for high-quality imaging. Automated alignments and data collection, combined with streamlined workflows in Thermo Scientific software, help enable faster, more consistent results across a range of user experience levels.
The Talos F200C TEM can be configured with CETA cameras for conventional TEM imaging, integrated STEM and EDX detectors for analytical applications, or the Falcon 4i Direct Electron Detector for cryo-EM workflows. This flexible platform supports a wide range of imaging and diffraction applications.
TEM/STEM components on Talos F200C for high-resolution and analytical imaging
High-Resolution X-FEG
200 kV X-FEG for high resolution and high-penetration depth
C-TWIN lens
Enhanced TEM contrast with the constant-power C-TWIN lens
Fully integrated detector options
Configure with Thermo Scientific Ceta 16M Camera for large field-of-view, fast imaging or Thermo Scientific Falcon 4i Direct Electron Detector for cryo-EM applications.
STEM detectors
Up to four-channel integrated STEM detectors and flexible EDS analysis options
Automated TEM/STEM workflows for reproducibility and ease of use
Reproducibility and ease of use with the Talos F200C TEM are supported by automation of daily alignments and image-quality-critical functions.
Commonly used tuning routines are automated within the TEM user interface and provided as standard features. These single-button alignments operate in both TEM and STEM modes and can serve as an alternative to manual alignments.
Key image-quality adjustments are also automated within the application software, offering consistent, single-button control of functions such as autofocus, eucentric height adjustment, and astigmatism correction (autostigmate).
Talos F200C TEM and STEM applications
Frequently asked questions about the Talos F200C TEM
The Talos F200C TEM includes a number of features that make it particularly appropriate for high-resolution biological applications ranging from biomaterials characterization to cryo-electron microscopy. This includes a retractable, automatic cryo-box, which protects cryogenically-preserved samples and helps to minimize ice growth. The instrument’s constant-power C-TWIN lens offers outstanding optical performance and stability, with a balance of contrast and resolution that is well suited for biological and soft matter samples. The high-brightness X-FEG electron source supports high-resolution imaging in both TEM and STEM modes, and electron acceleration can be tuned within the operating range of 20-200 kV, allowing you to optimize electron energy and penetration depth to match specific samples and applications.
Yes, the Talos F200C TEM is configured with cryo-EM applications in mind. This includes features such as the retractable cryo-box, which protects sensitive cryo-EM samples, as well as compatibility with Thermo Scientific cameras such as the Thermo Scientific Ceta S, Ceta D, and Falcon 4i Detectors, which are all optimized for imaging at the lower dose rates that are best suited for biological specimens. The instrument integrates with dedicated cryo-EM software packages from Thermo Fisher Scientific including Thermo Scientific Maps, EPU, and Tomography Software.
While the Talos F200C TEM is engineered to meet the needs of biological research, the instrument is highly flexible and can be configured for multidisciplinary and shared lab facilities. The instrument can operate at both cryogenic and room temperature conditions, enabling a full range of cryo-experiments as well as STEM imaging, energy-dispersive X-ray spectroscopy (EDS) mapping, electron diffraction, and more. Multiple, automated imaging applications and workflows are compatible with the Talos F200C TEM; this includes both 2D and 3D methods, such as tomography of plastic-embedded cells and tissue, single particle analysis of either vitrified proteins or purified nanoparticles, and electron diffraction of sub-micrometer crystals.
The Talos F200C TEM is intended to be accessible for multiple users with different backgrounds, facilitating various TEM and STEM workflows with advanced automation, enhanced ergonomics, and a user-friendly digital user interface. A variety of Thermo Scientific application software packages streamline workflows and optimize data collection for users at all experience levels. A SmartCam digital search-and-view camera simplifies interactive sample examination and allows for daylight operation, broadening the types of lab environments that the Talos F200C TEM can operate in. Automatic software-controlled switching of apertures and the retractable cryo-box offer fast and easy control of the microscope and facilitate remote operation for even more flexibility and convenience.
For Research Use Only. Not for use in diagnostic procedures.