Employ a catalyzed silylation reagent formulation, for derivatization of hydroxyls with the Thermo Scientific™ Tri-Sil TBT (TMSI:BSA:TMCS) Reagent. Composed of TMSI/BSA/TMCS (3:3:2), this catalyzed silylation reagent formulation typically reacts with hydroxyls in a short period of time at 60–80 °C to form TMS ethers. Highly hindered hydroxyls may require several hours.
Converts all classes of hydroxyl groups to TMS ethers
Under usual conditions, the reaction is complete in a short period of time at 60 to 80°C, although very hindered hydroxyls may require several hours
Limited warranty period: Subject to all warranty requirements and exclusions set out in our Terms and Conditions of Sale, this product is warranted from the date we ship the product and for ninety (90) days thereafter. Disclaimer to internal research use restriction: Any restrictions on the purchaser to utilize the product(s) for internal research purposes only does not apply to the product(s) on the web pages associated with this statement.
1. Seidel, V., et al. (1993). Chromatographia 37, 191-201.