'It is uncertain how antiviral lymphocytes are activated in draining lymph nodes, the site where adaptive immune responses are initiated. Here, using intravital microscopy we show that after infection of mice with vaccinia virus (a large DNA virus) or vesicular stomatitis virus (a small RNA virus), virions drained to the ... More
Lipid-dependent bidirectional traffic of apolipoprotein B in polarized enterocytes.
AuthorsMorel E, Demignot S, Chateau D, Chambaz J, Rousset M, Delers F
JournalMol Biol Cell
PubMed ID14565984
'Enterocytes are highly polarized cells that transfer nutrients across the intestinal epithelium from the apical to the basolateral pole. Apolipoprotein B (apoB) is a secretory protein that plays a key role in the transepithelial transport of dietary fatty acids as triacylglycerol. The evaluation of the control of apoB traffic by ... More
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.
AuthorsKaether C, Lammich S, Edbauer D, Ertl M, Rietdorf J, Capell A, Steiner H, Haass C
JournalJ Cell Biol
PubMed ID12147673
'Amyloid beta-peptide (Abeta) is generated by the consecutive cleavages of beta- and gamma-secretase. The intramembraneous gamma-secretase cleavage critically depends on the activity of presenilins (PS1 and PS2). Although there is evidence that PSs are aspartyl proteases with gamma-secretase activity, it remains controversial whether their subcellular localization overlaps with the cellular ... More
The yeast prion Ure2p native-like assemblies are toxic to mammalian cells regardless of their aggregation state.
AuthorsPieri L, Bucciantini M, Nosi D, Formigli L, Savistchenko J, Melki R, Stefani M
JournalJ Biol Chem
PubMed ID16571726
'The yeast prion Ure2p assembles in vitro into oligomers and fibrils retaining the alpha-helix content and binding properties of the soluble protein. Here we show that the different forms of Ure2p native-like assemblies (dimers, oligomers, and fibrils) are similarly toxic to murine H-END cells when added to the culture medium. ... More
Characterization of the extra-large G protein alpha-subunit XLalphas. I. Tissue distribution and subcellular localization.
AuthorsPasolli HA, Klemke M, Kehlenbach RH, Wang Y, Huttner WB
JournalJ Biol Chem
PubMed ID10931823
'Our group previously described a new type of G protein, the 78-kDa XLalphas (extra large alphas) (Kehlenbach, R. H., Matthey, J., and Huttner, W. B. (1994) Nature 372, 804-809 and (1995) Nature 375, 253). Upon subcellular fractionation, XLalphas labeled by ADP-ribosylation with cholera toxin was previously mainly detected in the ... More
In vivo expression of mammalian BiP ATPase mutants causes disruption of the endoplasmic reticulum.
'BiP possesses ATP binding/hydrolysis activities that are thought to be essential for its ability to chaperone protein folding and assembly in the endoplasmic reticulum (ER). We have produced a series of point mutations in a hamster BiP clone that inhibit ATPase activity and have generated a species-specific anti-BiP antibody to ... More
Polarized insertion of new membrane from a cytoplasmic reservoir during cleavage of the Drosophila embryo.
AuthorsLecuit T, Wieschaus E
JournalJ Cell Biol
PubMed ID10953008
'Cellularization of the Drosophila embryo is a specialized form of cytokinesis that results in the formation of a polarized epithelium. The mechanisms of membrane growth during cytokinesis are largely unknown. It is also unclear whether membrane growth and polarization represent distinct processes that occur simultaneously or whether growth of the ... More
Human erythrocytes adhering to schistosomula of Schistosoma mansoni lyse and fail to transfer membrane components to the parasite.
AuthorsCaulfield JP, Cianci CM
JournalJ Cell Biol
PubMed ID4008525
'We studied the adherence of human erythrocytes to larvae of the intravascular parasite Schistosoma mansoni by transmission microscopy, freeze fracture, and fluorescence techniques. In addition, we used the adherent cells to investigate the problem of host antigen acquisition. Schistosomula were cultured for from 24 to 48 h after transformation in ... More
Isolation of a cDNA encoding human lysophosphatidic acid phosphatase that is involved in the regulation of mitochondrial lipid biosynthesis.
AuthorsHiroyama M, Takenawa T
JournalJ Biol Chem
PubMed ID10506173
'In this study, we isolated cDNA encoding lysophosphatidic acid (LPA) phosphatase (LPAP). The amino acid sequence deduced from the cDNA encoding LPAP had 421 residues including a putative signal peptide and was homologous to acid phosphatase, especially at the active site. Human LPAP had 28.5% amino acid identity to human ... More
Characterization and imaging of A6 epithelial cell clones expressing fluorescently labeled ENaC subunits.
AuthorsBlazer-Yost BL, Butterworth M, Hartman AD, Parker GE, Faletti CJ, Els WJ, Rhodes SJ
JournalAm J Physiol Cell Physiol
PubMed ID11443062
'A6 model renal epithelial cells were stably transfected with enhanced green fluorescent protein (EGFP)-tagged alpha- or beta-subunits of the epithelial Na(+) channel (ENaC). Transfected RNA and proteins were both expressed in low abundance, similar to the endogenous levels of ENaC in native cells. In living cells, laser scanning confocal microscopy ... More
Disruption-induced mucus secretion: repair and protection.
AuthorsMiyake K, Tanaka T, McNeil PL,
JournalPLoS Biol
PubMed ID16933971
'When a cell suffers a plasma membrane disruption, extracellular Ca(2+) rapidly diffuses into its cytosol, triggering there local homotypic and exocytotic membrane fusion events. One role of this emergency exocytotic response is to promote cell survival: the internal membrane thus added to the plasma membrane acts as a reparative "patch." ... More
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo.
AuthorsBresnahan PA, Leduc R, Thomas L, Thorner J, Gibson HL, Brake AJ, Barr PJ, Thomas G
JournalJ Cell Biol
PubMed ID2269657
'Extracts from BSC-40 cells infected with vaccinia recombinants expressing either the yeast KEX2 prohormone endoprotease or a human structural homologue (fur gene product) contained an elevated level of a membrane-associated endoproteolytic activity that could cleave at pairs of basic amino acids (-LysArg- and -ArgArg-). The fur-directed activity (furin) shared many ... More
Application of fluorescently labelled lectins for the visualization and biochemical characterization of polysaccharides in biofilms of Pseudomonas aeruginosa.
AuthorsStrathmann M, Wingender J, Flemming HC
JournalJ Microbiol Methods
PubMed ID12031574
'Fluorescently labelled lectins were used in combination with epifluorescence microscopy and confocal laser scanning microscopy to allow the visualization and characterization of carbohydrate-containing extracellular polymeric substances (EPS) in biofilms of Pseudomonas aeruginosa. A mucoid strain characterized by an overproduction of the exopolysaccharide alginate, and an isogenic, non-mucoid strain were used. ... More
Conjugation of lectins with fluorochromes: an approach to histochemical double labeling of carbohydrate components.
AuthorsRoth J, Binder M, Gerhard UJ
JournalHistochemistry
PubMed ID80399
Methodical investigations on the coupling of lectins (Con A, LcL, WGA, RcA) to tetramethylrhodamine isothiocyan ate (TRITC) are reported. 20-microgram of TRITC per mg of lectin were found to be the optimal amount of TRITC for the conjugation. With this fluorochrome: protein ratio conjugates were produced which resulted in a ... More
Removal of osteoclast bone resorption products by transcytosis.
AuthorsSalo J, Lehenkari P, Mulari M, Metsikkö K, Väänänen HK
JournalScience
PubMed ID9092479
Osteoclasts are multinucleated cells responsible for bone resorption. During the resorption cycle, osteoclasts undergo dramatic changes in their polarity, and resorbing cells reveal four functionally and structurally different membrane domains. Bone degradation products, both organic and inorganic, were endocytosed from the ruffled border membrane. They were then found to be ... More
Fibroblasts contracting collagen matrices form transient plasma membrane passages through which the cells take up fluorescein isothiocyanate-dextran and Ca2+.
AuthorsLin YC, Ho CH, Grinnell F
JournalMol Biol Cell
PubMed ID9017595
When fibroblasts contract collagen matrices, the cells activate a Ca(2+)-dependent cyclic AMP signaling pathway. We have found that contraction also stimulates uptake of fluorescein isothiocyanate-dextran molecules from the medium. Our results indicate that fluorescein isothiocyanate-dextran enters directly into the cell cytoplasm through 3- to 5-nm plasma membrane passages. These passages, ... More
Possible involvement of heterotrimeric G proteins in the organization of the Golgi apparatus.
AuthorsYamaguchi T, Yamamoto A, Furuno A, Hatsuzawa K, Tani K, Himeno M, Tagaya M
JournalJ Biol Chem
PubMed ID9312142
Nordihydroguaiaretic acid (NDGA) caused disassembly of the Golgi apparatus of NRK cells in a dose-, time-, and energy-dependent manner but not in a microtubule-dependent manner. In contrast to brefeldin A, NDGA did not cause release of beta-COP, a component of Golgi-derived vesicles. However, NDGA-induced disassembly was blocked by AlF4-, an ... More
Schistosoma mansoni: visualization with fluorescent lectins of secretions and surface carbohydrates of living cercariae.
AuthorsLinder E
JournalExp Parasitol
PubMed ID3996523
Attachment of Schistosoma mansoni cercariae was studied during their explorative movements along a glass surface using labeled lectins as markers. Fluorochrome-labeled lectins selectively labeled surface material produced at the cercarial attachment sites and part of the cercarial surface. The deposited secretions reacted with most of the lectins used but differences ... More
Wheat germ agglutinin blocks the acrosome reaction in Strongylocentrotus purpuratus sperm by binding a 210,000-mol-wt membrane protein.
AuthorsPodell SB, Vacquier VD
JournalJ Cell Biol
PubMed ID6092388
Wheat germ agglutinin (WGA) binds to the entire surface of Strongylocentrotus purpuratus sperm, and inhibits the egg jelly-induced acrosome reaction. The binding was found to be species dependent and was completely inhibited by 5 mM N-acetyl-D-glucosamine. Blockage of the acrosome reaction by WGA was bypassed by a combination of the ... More
Selective chemical treatment of cellular microdomains using multiple laminar streams.
AuthorsTakayama S, Ostuni E, LeDuc P, Naruse K, Ingber DE, Whitesides GM
JournalChem Biol
PubMed ID12618184
There are many experiments in which it would be useful to treat a part of the surface or interior of a cell with a biochemical reagent. It is difficult, however, to achieve subcellular specificity, because small molecules diffuse distances equal to the extent of the cell in seconds. This paper ... More
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress.
AuthorsStamer K, Vogel R, Thies E, Mandelkow E, Mandelkow EM
JournalJ Cell Biol
PubMed ID11901170
We studied the effect of microtubule-associated tau protein on trafficking of vesicles and organelles in primary cortical neurons, retinal ganglion cells, and neuroblastoma cells. Tau inhibits kinesin-dependent transport of peroxisomes, neurofilaments, and Golgi-derived vesicles into neurites. Loss of peroxisomes makes cells vulnerable to oxidative stress and leads to degeneration. In ... More
Characterization of the cytosolic tuberin-hamartin complex. Tuberin is a cytosolic chaperone for hamartin.
AuthorsNellist M, van Slegtenhorst MA, Goedbloed M, van den Ouweland AM, Halley DJ, van der Sluijs P
JournalJ Biol Chem
PubMed ID10585443
Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by a broad phenotypic spectrum that includes seizures, mental retardation, renal dysfunction and dermatological abnormalities. Mutations to either the TSC1 or TSC2 gene are responsible for the disease. The TSC1 gene encodes hamartin, a 130-kDa protein without significant homology to other ... More
Inhibition of glycosylation induces formation of open connexin-43 cell-to-cell channels and phosphorylation and triton X-100 insolubility of connexin-43.
AuthorsWang Y, Mehta PP, Rose B
JournalJ Biol Chem
PubMed ID7592880
We transfected the cDNA for the cell-to-cell channel protein connexin-43 (Cx43) into Morris hepatoma H5123 cells, which express little Cx43 and lack gap junctional communication (open cell-to-cell channels). We found that cells overexpressing Cx43 nonetheless lacked open cell-to-cell channels, but that inhibition of glycosylation by tunicamycin induced open channels in ... More
Alterations in glomerular lectin binding sites of human kidney as detected by fluorescence microscopy.
AuthorsHolthöfer H, Virtanen I, Törnroth T, Miettinen A
JournalHistochem J
PubMed ID2415488
Different lectins were used to study frozen sections of kidney samples showing alterations in routine immunofluorescence studies. Arachis hypogaea agglutinin (peanut lectin, PNA), lacking binding sites in normal glomeruli, bound to the glomeruli in two of the five samples studied, giving a granular fluorescence pattern. Concomitantly with the appearance of ... More
Spatial and temporal colocalization of the Golgi apparatus and microtubules rich in detyrosinated tubulin.
AuthorsSkoufias DA, Burgess TL, Wilson L
JournalJ Cell Biol
PubMed ID2229182
The integrity and intracellular distribution of the Golgi apparatus appear to depend upon microtubules. We have found that the microtubules rich in detyrosinated tubulin are located preferentially in the vicinity of the Golgi. Cells were double-stained with antibodies specific for either tyrosinated or detyrosinated tubulin and an antibody to prolactin ... More
Localized calcium signals along the cleavage furrow of the Xenopus egg are not involved in cytokinesis.
AuthorsNoguchi T, Mabuchi I
JournalMol Biol Cell
PubMed ID11950937
It has been proposed that a localized calcium (Ca) signal at the growing end of the cleavage furrow triggers cleavage furrow formation in large eggs. We have examined the possible role of a Ca signal in cleavage furrow formation in the Xenopus laevis egg during the first cleavage. We were ... More
Helix pomatia agglutinin binds specifically to the Golgi apparatus in cultured human fibroblasts and reveals two Golgi apparatus-specific glycoproteins.
AuthorsVirtanen I
JournalHistochemistry
PubMed ID2228736
Fluorochrome-coupled Helix pomatia agglutinin (HPA), but not other lectin-conjugates with the same nominal specificity, bound specifically to the Golgi apparatus in cultured human fibroblasts, revealing a cytoplasmic juxtanuclear reticular structure. Unlike other Golgi-binding lectins the HPA-conjugates did not bind to the cell surface membrane or pericellular matrix. Experiments with 35S-methionine-labeled ... More
Wheat germ agglutinin conjugated to TRITC: a novel approach for labeling primary projection neurons of peripheral afferent nerves.
AuthorsSawczuk A, Covell DA
JournalJ Neurosci Methods
PubMed ID10634499
Wheat germ agglutinin conjugated to tetramethylrhodamine isothiocyanate-dextran (WGA-TRITC) was studied as a novel tracer of primary projection neurons of pharyngeal (PhN) and superior laryngeal (SLN) branches of the vagus nerve. The SLN and PhN were dissected from rat cervical tissues and the proximal end of the nerves were bathed in ... More
Regulation of pH by the M2 protein of influenza A viruses.
AuthorsCiampor F, Thompson CA, Grambas S, Hay AJ
JournalVirus Res
PubMed ID1626420
Inhibition of the function of the M2 protein by amantadine can cause a conformational change in the haemagglutinin (HA) of H7 influenza A viruses and the consequent expression of the low pH form of the glycoprotein on the surface of virus-infected cells. Immunofluorescence studies showed that this conversion occurs shortly ... More
A novel phosphatidylinositol-5-phosphate 4-kinase (phosphatidylinositol-phosphate kinase IIgamma) is phosphorylated in the endoplasmic reticulum in response to mitogenic signals.
AuthorsItoh T, Ijuin T, Takenawa T
JournalJ Biol Chem
PubMed ID9685379
Here, we identify a novel rat phosphatidylinositol-5-phosphate 4-kinase, phosphatidylinositol-phosphate kinase IIgamma (PIPKIIgamma). PIPKIIgamma comprises 420 amino acids with a molecular mass of 47,048 Da, showing greater homology to the type IIalpha and IIbeta isoforms (61.1 and 63.7% amino acid identities, respectively) of phosphatidylinositol-phosphate kinase than to the type I isoforms. ... More
Multivariate analysis and list mode processing of murine hemopoietic subpopulations for cytokinetic studies.
AuthorsPallavicini MG, Summers LJ, Giroud FJ, Dean PN, Gray JW
JournalCytometry
PubMed ID3840733
Multivariate analyses and list mode data processing were used to obtain cytokinetic information on flow cytometrically distinct hemopoietic subpopulations. In one application, viable, unfixed hemopoietic subpopulations were discriminated on the basis of cyanine dye fluorescence and orthogonal light scatter; Hoechst dye fluorescence was measured to determine the proliferative status of ... More
Dynamic association of proteasomal machinery with the centrosome.
AuthorsWigley WC, Fabunmi RP, Lee MG, Marino CR, Muallem S, DeMartino GN, Thomas PJ
JournalJ Cell Biol
PubMed ID10225950
Although the number of pathologies known to arise from the inappropriate folding of proteins continues to grow, mechanisms underlying the recognition and ultimate disposition of misfolded polypeptides remain obscure. For example, how and where such substrates are identified and processed is unknown. We report here the identification of a specific ... More
Studies of transferrin recycling reconstituted in streptolysin O permeabilized Chinese hamster ovary cells.
AuthorsMartys JL, Shevell T, McGraw TE
JournalJ Biol Chem
PubMed ID7592788
Efficient transferrin receptor recycling is reconstituted when donor cytosol and ATP are added to the streptolysin O permeabilized cells. The rate of reconstituted recycling is dependent on the concentration of donor cytosol. The cytosol provides a factor(s) required for the transport of transferrin from the pericentriolar recycling compartment to the ... More
Uncoupling of chondroitin sulfate glycosaminoglycan synthesis by brefeldin A.
AuthorsSpiro RC, Freeze HH, Sampath D, Garcia JA
JournalJ Cell Biol
PubMed ID1955486
Brefeldin A has dramatic, well-documented, effects on the structural and functional organization of the Golgi complex. We have examined the effects of brefeldin A (BFA) on the Golgi-localized synthesis and addition of chondroitin sulfate glycosaminoglycan carbohydrate side chains. BFA caused a dose-dependent inhibition of chondroitin sulfate glycosaminoglycan elongation and sulfation ... More
Distribution and lateral mobility of glycine receptors on cultured spinal cord neurons.
AuthorsSrinivasan Y, Guzikowski AP, Haugland RP, Angelides KJ
JournalJ Neurosci
PubMed ID2156968
Strychnine is one of the most potent antagonists of glycine-mediated inhibitory conductances in the mammalian spinal cord. In order to examine the distribution of glycine receptors (GlyRs) on neuronal cells, 2 novel fluorescent strychnine derivatives were synthesized and characterized chemically, spectroscopically, and biologically. Both compounds retain their biological activity after ... More
Immunolocalization of kinesin in sea urchin coelomocytes. Association of kinesin with intracellular organelles.
AuthorsHenson JH, Nesbitt D, Wright BD, Scholey JM
JournalJ Cell Sci
PubMed ID1478935
We have recently used domain-specific monoclonal antibodies (mAbs) to immunofluorescently localize kinesin to vesicle-like structures in the cytoplasm of sea urchin coelomocytes. In order to characterize further these localization patterns we have examined the distribution of kinesin with respect to the arrangement of microtubules (MTs) and various organelles. In double-label ... More
Cellular origin of fibronectin in interspecies hybrid kidneys.
AuthorsSariola H, Kuusela P, Ekblom P
JournalJ Cell Biol
PubMed ID6389571
The cellular origin of fibronectin in the kidney was studied in three experimental models. Immunohistochemical techniques that use cross-reacting or species-specific antibodies against mouse or chicken fibronectin were employed. In the first model studied, initially avascular mouse kidneys cultured on avian chorioallantoic membranes differentiate into epithelial kidney tubules and become ... More
Identification of components of the endoplasmic reticulum and Golgi complex by murine autoreactive monoclonal antibodies.
AuthorsKooy J, Underwood JR, Gleeson PA
JournalImmunology
PubMed ID2026449
A number of autoreactive monoclonal antibodies have been produced by the fusion of spleen cells from unprimed BALB/c mice. The specificities of two of these monoclonal autoantibodies, MUI 38 and MUI 100, have been further examined. By indirect immunofluorescence, monoclonal antibody MUI 38 showed discrete perinuclear staining of acetone-fixed murine ... More
Rabies virus entry at the neuromuscular junction in nerve-muscle cocultures.
AuthorsLewis P, Fu Y, Lentz TL
JournalMuscle Nerve
PubMed ID10797395
Early events in rabies virus entry into neurons were investigated in chick spinal cord-muscle cocultures. Rabies virus (CVS strain) was adsorbed to the surface of cells in the cold. At times up to 10 min of warming to 37 degrees C, virus was most intensely localized to dense swellings on ... More
Involvement of the pleckstrin homology domain in the insulin-stimulated activation of protein kinase B.
AuthorsSable CL, Filippa N, Filloux C, Hemmings BA, Van Obberghen E
JournalJ Biol Chem
PubMed ID9792669
Involvement of the pleckstrin homology (PH) domain in the insulin-stimulated activation of protein kinase B (PKB) was investigated in human embryonic kidney 293 cells. Different PKB constructs that contain mutations or deletions in the PH domain were transfected into cells, and the results on the basal and insulin-induced kinase activities ... More
Distribution of gap junctions in dog and rat ventricle studied with a double-label technique.
AuthorsDolber PC, Beyer EC, Junker JL, Spach MS
JournalJ Mol Cell Cardiol
PubMed ID1338112
To assess the distribution of gap junctions in relation to the cardiac myocyte surface in paraffin sections of dog and rat ventricle, the sarcolemma was labeled with wheat germ agglutinin (WGA1) and gap junctions were labeled with antibodies to cardiac muscle gap junction protein connexin43. WGA labeled all of the ... More
The root endophytic fungus Piriformospora indica requires host cell death for proliferation during mutualistic symbiosis with barley.
AuthorsDeshmukh S, Hückelhoven R, Schäfer P, Imani J, Sharma M, Weiss M, Waller F, Kogel KH
JournalProc Natl Acad Sci U S A
PubMed ID17116870
Fungi of the recently defined order Sebacinales (Basidiomycota) are involved in a wide spectrum of mutualistic symbioses (including mycorrhizae) with various plants, thereby exhibiting a unique potential for biocontrol strategies. The axenically cultivable root endophyte Piriformospora indica is a model organism of this fungal order. It is able to increase ... More
Deletions into an NH2-terminal hydrophobic domain result in secretion of rotavirus VP7, a resident endoplasmic reticulum membrane glycoprotein.
AuthorsPoruchynsky MS, Tyndall C, Both GW, Sato F, Bellamy AR, Atkinson PH
JournalJ Cell Biol
PubMed ID2999159
Rotavirus, a non-enveloped reovirus, buds into the rough endoplasmic reticulum and transiently acquires a membrane. The structural glycoprotein, VP7, a 38-kD integral membrane protein of the endoplasmic reticulum (ER), presumably transfers to virus in this process. The gene for VP7 potentially encodes a protein of 326 amino acids which has ... More
Altered expression of monocyte IgA Fc receptors is associated with defective endocytosis in patients with alcoholic cirrhosis. Potential role for IFN-gamma.
AuthorsSilvain C, Patry C, Launay P, Lehuen A, Monteiro RC
JournalJ Immunol
PubMed ID7636220
Expression, saturation, and endocytosis of IgA Fc receptors (Fc alpha R) were analyzed in blood phagocytic cells of patients with alcoholic liver cirrhosis (ALC). Surface Fc alpha R expression was decreased in monocytes but not in neutrophils, as evaluated by IgA binding and anti-Fc alpha R mAb. The Fc alpha ... More
Forskolin-induced cell shrinkage and apical translocation of functional enhanced green fluorescent protein-human alphaENaC in H441 lung epithelial cell monolayers.
AuthorsWoollhead AM, Baines DL
JournalJ Biol Chem
PubMed ID16373340
Elevation of intracellular cAMP increases fluid re-absorption in the lung by raising amiloride-sensitive Na+ transport through the apically localized epithelial, amiloride-sensitive Na+ channel (ENaC). However, the signaling pathways mediating this response are still not fully understood. We show that inhibition of protein-tyrosine kinase (PTK) with Genistein and protein kinase A ... More
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
Authors
JournalNat Commun
PubMed ID30568254
The transcription factor Ndt80 is a repressor of Candida parapsilosis virulence attributes.
Authors
JournalVirulence
PubMed ID33538224
Penetration of CdSe/ZnS quantum dots into differentiated vs undifferentiated Caco-2 cells.
Authors
JournalJ Nanobiotechnology
PubMed ID27669686
Patient-Derived Organotypic Epithelial Rafts Model Phenotypes in Juvenile-Onset Recurrent Respiratory Papillomatosis.
Authors
JournalViruses
PubMed ID33418959
Imaging Reveals the Connection Between Spontaneous Coronary Plaque Ruptures, Atherothrombosis, and Myocardial Infarctions in HypoE/SRBI-/- Mice.
Authors
JournalJ Nucl Med
PubMed ID27127225
Inherited DNA Repair Defects Disrupt the Structure and Function of Human Skin.
Authors
JournalCell Stem Cell
PubMed ID33232662
Genetic deletion of SEPT7 reveals a cell type-specific role of septins in microtubule destabilization for the completion of cytokinesis.
Authors
JournalPLoS Genet
PubMed ID25122120
The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells.
Authors
JournalNat Commun
PubMed ID33753734
Nuclear Pores Assemble from Nucleoporin Condensates During Oogenesis.
Authors
JournalCell
PubMed ID31626769
Endothelial EphB4 maintains vascular integrity and transport function in adult heart.