BioPharma Finder™ Software for the Characterization of Biotherapeutics

Thermo Scientific™ BioPharma Finder™ software offers purpose-built data processing, curation, and reporting in a connected environment, enabling streamlined collaboration on a local and global scale. Simplify the characterization of biotherapeutic attributes with advanced capabilities that increase efficiency and confidence in BioPharma workflows. Leverage the high quality HRAM data generated by Thermo Scientific™ Orbitrap™ mass spectrometers, to efficiently screen, identify, and characterize proteins and oligonucleotides with greater productivity and confidence. Experience the power of BioPharma Finder software connected to the Thermo Scientific™ Ardia™ Platform to unlock enhanced features including data security, remote accessibility, collaboration tools, and interactive reporting, all tailored to streamline your BioPharma workflows.

Workflow-driven characterization, method processing, and result review

Peptide mapping workflow:

• Validate amino acid assignments with a novel MS2 prediction algorithm, providing an added layer of certainty to confirm the accuracy of the amino acid sequence
• Characterize site-specific expected and unknown post-translational modifications (PTMs), and utilize error-tolerant searches to identify unexpected modifications
• Map disulfide bonds, create de novo sequence searches, and accurately detect low-level impurities and sequence variants for comprehensive analysis
• Experience streamlined processes, including the Multi-Attribute Method (MAM) workflow to span from discovery peptide mapping to critical quality attributes (CQAs) monitoring in GMP environments

Oligonucleotide workflow:

• Automated annotation and confirmation of oligonucleotide sequence with a novel MS2 prediction algorithm
• Construct oligonucleotide sequences with built in customized building block subunits, including base, backbone linker, 2' ribose, 3' terminal and 5' terminal

Intact protein workflow:

• Rapidly measure the intact molecular weight of biotherapeutics, including proteins and oligonucleotides, with built in deconvolution algorithms
• Protein sequence matching to annotate N-linked glycosylations and common modifications
• Confident identification of Antibody Drug Conjugates (ADC) and Drug Antibody Ratio (DAR) determination using sliding window algorithm

Top down workflow:

• Features a simple workflow for sequencing intact protein molecules using ProSightBP as the core algorithm
• Includes multiple raw file comparison with combined interactive fragmentation coverage maps
• Supports multiple modes of fragmentation CID, HCD, ETD, EThcD and UVPD

Ardia Platform:

• Features: Reporting, data security, collaboration