Thermo Scientific™

Orbitrap™ Astral™ Zoom Mass Spectrometers

Name: Orbitrap™ Astral™ Zoom Mass Spectrometers
SKU: BRE725770

Realize a universe of possibilities with the Thermo Scientific™ Orbitrap™ Astral™ Zoom mass spectrometer with increased flexibility, faster throughput, deeper coverage, higher sensitivity, and accurate and precise quantitation.

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Catalog Number	Model	Mass Range
BRE725770	BioPharma option for Orbitrap Astral Zoom Mass Spectrometer	40 to 8000 m/z
BRE725700	Orbitrap Astral Zoom Mass Spectrometer	40 to 6000 m/z

2 Options

Catalog number BRE725770

Price (USD)

Model:

BioPharma option for Orbitrap Astral Zoom Mass Spectrometer

Mass Range:

40 to 8000 m/z

Accelerate discoveries forward with increased flexibility, faster throughput, deeper coverage, higher sensitivty, and accurate and precise quantitation with the Orbitrap Astral Zoom mass spectrometer. Designed to achieve the next generation of breakthroughs in proteomics, metabolomics, lipidomics, and biopharma research with faster scan rates, improved duty cycle, sub-cellular sensitivity, and novel acquisition methods. Turn ideas into insights, advancing science exponentially and driving clinical research forward to interventions that improve outcomes.

Upgraded instrument architecture leveraging the power of parallelized high-resolution accurate mass acquisition with the Orbitrap and Astral analyzers to enable:

Faster throughput

Identify over 8,000 proteins from 300 samples per day

Deeper coverage

Identify over 200,000 unique peptides from a single-shot experiment in under 1 hour
Comprehensively characterize small molecule samples with fragmentation of over 90% of compounds in a single injection with data-dependent acquisition

Higher sensitivity

Identify over 5,500 proteins from a single cell at a throughput of 50 samples per day

Accurate and Precise Quantitation

Achieve a linear dynamic range of 6 orders of magnitude for metabolites using simultaneous quantitation and discovery (SQUAD) workflows
Increase multiplexing with TMT HR mode to support TMTpro 35plex label reagents experiments

Increased Flexibility

Perform rapid intact, top-down, and middle-down measurements with the Biopharma option, enabling improved pressure regulation, an extended Orbitrap analyzer scan range up to m/z 8,000, and top-down and middle-down MS2 measurements with the Astral analyzer
Leverage faster stepped collision energy to increase spectral quality at speed for applications including N-linked glycoproteomics and metabolomics

Our general purpose product lines are not intended for in vitro diagnostic purposes in accordance with our product documentation, manuals, and labels. They are designated for General Laboratory Use Only.

Our general purpose product lines have not been tested or validated for such applications and their use for in vitro diagnostic purposes may result in health and safety risks.

For General Lab Use Only. Not For Diagnostic Procedures.

Specifications

Dimensions (D x W x H)185 x 96 x 140 cm

Dynamic Range5 orders of magnitude intrascan dynamic range

Mass Accuracy<3 ppm RMS with external calibration, <1 ppm RMS with internal calibration

ModelBioPharma option for Orbitrap Astral Zoom Mass Spectrometer

Scan RatesUp to 270 Hz

Weight (Metric)680 kg

Mass Range40 to 8000 m/z

Max. ResolutionUp to 480,000 at 200 m/z

TypeOrbitrap Astral LC-MS

Unit SizeEach

Frequently asked questions (FAQs)

What sensitivity or low-input sample performance advantages do the Orbitrap Astral MS and Orbitrap Astral Zoom MS systems provide?

The Thermo Scientific Orbitrap Astral MS introduces improved front-end ion optics (e.g., high-capacity ion transfer tube, electrodynamic ion funnel) and a novel Astral analyzer, enabling increased ion flux and lower detection limits. In the Orbitrap Astral Zoom MS, additional hardware features such as the “Bent Trap” pre-accumulation, “Low-Input Mode,” and enhanced duty cycle further improve sensitivity—supporting applications which include single-cell proteomics and low-material immunopeptidomics.

What mass-range is available on the Orbitrap Astral and Orbitrap Astral Zoom and what is the range of application coverage?

For both Thermo Scientific Orbitrap Astral Mass Spectrometers, the standard mass-range is m/z 40–6000 (for the 6000 version) and optionally m/z 40–8000 when a BioPharma option is selected. This extended range and flexibility supports workflows for protein profiling up to intact-protein/top-down biotherapeutic characterization—offering broader application coverage than many dedicated single-technique MS systems.

How does scan-rate and throughput on the Orbitrap Astral and Orbitrap Astral Zoom systems compare to legacy HRAM instruments?

The Thermo Scientific Orbitrap Astral MS features MS² acquisition rates up to 200 Hz with the Astral analyzer. The Astral Zoom MS advances this further, offering up to ~270 Hz MS² scan rates, enabling much higher sample throughput—e.g., processing ~300 samples per day in proteomics workflows. These improvements translate into faster gradient runs, more MS² events per chromatographic peak, and higher throughput than many previous generation HRAM systems.