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Thermo Scientific Chemicals
1-Methyl-1H-pyrazole-4-boronic acid pinacol ester, 97%, Thermo Scientific Chemicals
| Catalog Number | Quantity |
|---|---|
| H53139.03 also known as H53139-03 | 1 g |
Catalog number H53139.03
also known as H53139-03
Price (USD)
-
Quantity:
1 g
Chemical Identifiers
CAS761446-44-0
IUPAC Name1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole
Molecular FormulaC10H17BN2O2
InChI KeyUCNGGGYMLHAMJG-UHFFFAOYSA-N
SMILESCN1C=C(C=N1)B1OC(C)(C)C(C)(C)O1
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Specifications
Specification Sheet
Specification SheetAssay (GC)96.0% min
It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Applications
It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Solubility
Slightly soluble in water.
Notes
Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.
It is a reagent used for Suzuki-Miyaura cross-coupling reactions, transesterification reactions. It is involved in several reactions as a reagent for the preparation of aminothiazoles as γ-secretase modulators,amino-pyrido-indol-carboxamides, as potential JAK2 inhibitors for myeloproliferative disorders therapy, pyridine derivatives as TGF-β1 and active A signaling inhibitors and MK-2461 analogs as inhibitors of c-Met kinase for the treatment of cancer.
Solubility
Slightly soluble in water.
Notes
Store in cool dry place. Ensure proper ventilation. Incompatible with oxidizing agents.
RUO – Research Use Only
General References:
- Peter R. Mullens. An improved synthesis of 1-methyl-1H-pyrazole-4-boronic acid pinacol ester and its corresponding lithium hydroxy ate complex: application in Suzuki couplingsTetrahedron Lett 2009, 50 (49),6783-6786 .
- Minhang Xin.; Jun Wen.; Feng Tang.; Chongxing Tu.; Han Shen.; Xinge Zhao. The discovery of novel N-(2-pyrimidinylamino) benzamide derivatives as potent hedgehog signaling pathway inhibitors.bioorg med chem lett. 2013, 23 (24), 6777-6783 .