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Thermo Scientific™
Q Exactive™ Focus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer
Making the sensitivity, selectivity, simplicity and durability of hybrid quadrupole-Orbitrap mass spectrometry accessible to more laboratories.
| Catalog Number | Scan Rates | Resolution | Mass Range |
|---|---|---|---|
| IQLAAEGAAPFALGMBHE | Up to 12 Hz | 70,000 at m/z 200 | 50 to 3000 m/z |
Catalog number IQLAAEGAAPFALGMBHE
Price (USD)
-
Scan Rates:
Up to 12 Hz
Resolution:
70,000 at m/z 200
Mass Range:
50 to 3000 m/z
The sensitivity, selectivity, flexibility, and ease-of-use provided by hybrid quadrupole-Orbitrap mass spectrometers set the standard for screening, quantitation, identification, and confirmation of targeted and untargeted compounds. The Thermo Scientific™ Q Exactive™ Focus hybrid quadrupole-Orbitrap MS makes this power accessible to environmental, food safety, clinical research, forensic toxicology, and pharmaceutical labs challenged by growing sample volumes and constrained by strict budgets. The Q Exactive Focus system simplifies method development, saving time and decreasing costs while reliably delivering unsurpassed results.
Precision hardware
Thermo Scientific Ion Max API Source- H-ESI II probe with dual desolvation zone technology
- Sweep gas to reduce chemical noise
- 60° interchangeable ion probe orientation
- Removable metal ion transfer capillary provides vent-free maintenance Vacuum System
- Differentially pumped vacuum system with final vacuum <1 x 10⁻⁹
- Two split-flow turbomolecular pumps and one rotary vane pump
- Seven vacuum regions
- Thermo Scientific™ HyperQuad™ mass filter provides increased ion transmission
- Variable precursor ion isolation width selection from 0.4 Da to full mass range
- RF lens stacked-ring radio frequency ion guide captures and efficiently focuses the ions into a tight beam. Large variable spacing between electrodes allows for better pumping efficiency and improved ruggedness.
- Bent flatapole ion guide reduces noise by preventing neutrals and high-velocity clusters from entering the quadrupole
- Nitrogen-filled C-Trap
- Highly efficient ion transfer to Thermo Scientific™ Orbitrap™ mass analyzer
- Straight multipole collision cell for HCD
- Orbitrap mass analyzer with 5 kV central electrode voltage
- Low-noise image current preamplifier
- 16-bit signal digitalization
- Ultrafast real-time data acquisition and instrument control system
- Fully automated calibration via instrument control software
- Automatic Gain Control
The Q Exactive Focus mass spectrometer combines quadrupole precursor selection with high-resolution, accurate-mass detection to produce sensitivity that rivals triple quadrupole mass spectrometers and resolution that surpasses Q-TOF instruments.
- Exceptional sensitivity thanks to superior selectivity that eliminates interferences allowing lower limits of detection and quantitation
- Fast polarity switching so more classes of compounds can be processed in a single analysis
- High scan speeds for compatibility with fast chromatography and high-throughput screening
- Resolution superior to Q-TOF instruments for more confident identification and confirmation
- Exceptionally wide linear dynamic range
The unique hybrid quadrupole-Orbitrap configuration provides exceptional flexibility, allowing Q Exactive Focus instruments to perform both targeted and untargeted screening with confident identification and confirmation. Q Exactive Focus instruments can take advantage of high-resolution, accurate-mass in a number of quantification approaches, including:
- Full-scan – data-dependent MS/MS (FS-ddMS2) acquisition for ultimate scan speed and quantitative performance
- *Variable data-independent acquisition (vDIA) for qualitative coverage for screening unknowns without compromising quantitative performance
- Selected-ion monitoring (SIM) for simple setup and highest sensitivity
- Parallel-reaction monitoring (PRM) for high selectivity and high throughput with confident confirmation
Application-specific software is available to make full use of the power of the Q Exactive Focus instrument. The system’s unique data acquisition function enables ultrafast real-time data acquisition and instrument control, fully automated calibration via instrument control software, and automatic gain control.
For component identification during targeted and untargeted analysis, the Thermo Scientific™ TraceFinder™ software includes libraries of high-resolution accurate-mass (HRAM) spectra. Compounds commonly targeted in food and environmental analyses, and in clinical research and forensic/toxicological studies, are represented by several thousand HRAM spectra. Combined with TraceFinder data analysis software, the Q Exactive Focus offers a powerful, yet simple-to-use solution for food safety, environmental, clinical research, forensic, and toxicological screening.
For research use only. Not for use in diagnostic procedures.
*vDIA method is not available in the United States
Specifications
Dynamic Range>5000:1
Mass AccuracyInternal: <1 ppm RMS, External: <3 ppm RMS
Polarity SwitchingOne Full Cycle in <1 Sec (One Full Positive Mode Scan and One Full Negative Mode Scan (at a Resolution Setting of 35,000))
Scan RatesUp to 12 Hz
SensitivityFull MS: 500 fg Buspirone on Column S/N 100:1 SIM: 50 fg Buspirone on Column S/N 100:1
Mass Range50 to 3000 m/z
Resolution70,000 at m/z 200
TypeQuadrupole-Orbitrap LC-MS
Unit SizeEach