N-hidroxisucinimida, 98+ %, Thermo Scientific Chemicals

Name: N-hidroxisucinimida, 98+ %, Thermo Scientific Chemicals
SKU: A10312.22

CAS: 6066-82-6 | C4H5NO3 | 115.088 g/mol

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25 g

100 g

500 g

Número de catálogo A10312.22

también denominado A10312-22

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100 g

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Identificadores químicos

CAS6066-82-6

IUPAC Name1-hydroxypyrrolidine-2,5-dione

Molecular FormulaC4H5NO3

InChI KeyNQTADLQHYWFPDB-UHFFFAOYSA-N

SMILESON1C(=O)CCC1=O

Especificaciones Specification Sheet

Hoja de especificaciones

Assay from Supplier's CofA≥98.0% (U.S. specification)

Water Content (Karl Fischer Titration)≤1.0%

Assay (Aqueous acid-base Titration)≥98.0 to ≤102.0% (non-U.S. specification)

Identification (FTIR)Conforms (non-U.S. specification)

FormCrystals or powder or crystalline powder or fused solid

N-Hydroxysuccinimide is used for improved amidations in the carbodiimide method. It is also used to activate a carboxyl group and reacts with amine to form amide. It is involved in the preparation of N-hydroxymaleimide-styrene copolymer. Further, it finds use in analytical chemistry. As an additive, it is used in the carbodiimide method for improved amidations and peptide couplings.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
La N-hidroxisuccinimida se utiliza para mejorar las amidaciones en el método carbodiimida. También se usa para activar un grupo carboxilo y reacciona con la amina para formar la amida. Participa en la preparación de copolímero de N-hidroximaleimida-estireno y se usa en química analítica. Además, se utiliza como aditivo en el método carbodiimida para mejorar las amidaciones y los acoplamientos peptídicos.

Solubilidad
Soluble en agua, dimetilformamida, alcoholes y acetato de etilo. Insoluble en éter frío.

Notas
Higroscópica. Sensible a la humedad. Incompatible con agentes oxidantes fuertes, cloruros ácidos, anhídridos ácidos y bases fuertes. Almacenar en lugar fresco.

RUO – Research Use Only

General References:

Reagent for the preparation of active N-hydroxysuccinimide esters for peptide coupling with minimum racemization: J. Am. Chem. Soc., 86, 1839 (1964), or as an additive in the DCC method (see N,N'-Dicyclohexyl carbodiimide, A10973 ) to suppress racemization: J. Am. Chem. Soc., 89, 7151 (1967). For peptide reagents, see Appendix 6.
For a study of the aminolysis of N-hydroxysuccinimide esters, see: J. Org. Chem., 53, 3583 (1988).
Park, C.; Vo, C. L. N.; Kang, T.; Oh, E.; Lee, B. J. New method and characterization of self-assembled gelatin-oleic nanoparticles using a desolvation method via carbodiimide-hydroxysuccinimide (EDCHS) reaction. Eur. J. Pharm. Biopharm. 2015, 89, 365-373.
Peng, Z.; McGee, W. M.; Bu, J.; Barefoot, N. Z.; McLuckey, S. A. Gas phase reactivity of carboxylates with N-hydroxysuccinimide esters. J. Am. Soc. Mass. Spectrom. 2015, 26 (1), 174-180.