Clorhidrato de piridina, 98 %, Thermo Scientific Chemicals

Name: Clorhidrato de piridina, 98 %, Thermo Scientific Chemicals
SKU: A10871.18

CAS: 628-13-7 | C5H6ClN | 115.56 g/mol

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50 g

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Número de catálogo A10871.18

también denominado A10871-18

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50 g

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Identificadores químicos

CAS628-13-7

IUPAC Namepyridin-1-ium chloride

Molecular FormulaC5H6ClN

InChI KeyAOJFQRQNPXYVLM-UHFFFAOYSA-N

SMILES[Cl-].C1=CC=[NH+]C=C1

Especificaciones Specification Sheet

Hoja de especificaciones

Appearance (Color)White to cream

FormCrystals or powder or crystalline powder or lumps or fused solid

Water Content (Karl Fischer Titration)≤1.5%

Assay (Freebase GC)≥97.5%

Identification (FTIR)Conforms

Pyridine hydrochloride is a classical reagent for cleavage of aryl methyl ethers at 200-220o. It is also used in the demethylation of 4,5-dimethyl-7-methoxy-1-tetralone.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
El clorhidrato de piridina es un reactivo clásico para la escisión de los éteres de metilo arílico en 200-220o. También se utiliza en la desmetilación de 4,5-dimetil-7-metoxi-1-tetralona.

Solubilidad
Soluble en agua (85 g/100 ml) y metanol.

Notas
Almacenar en un lugar fresco. Mantener el recipiente bien cerrado en un lugar seco y bien ventilado. Es higroscópico en la naturaleza.

RUO – Research Use Only

General References:

William G. Dauben.; Gerhard J. Fonken. Trofimov. Isomerization of Isospirostans to Furostenols with Pyridine Hydrochloride as the Catalyst. J. Am. Chem. Soc. 1954, 76, (18), 4618-4619.
T. S. Hamilton.; Roger Adams. Reduction Of Pyridine Hydrochloride And Pyridonium Salts By Means Of Hydrogen And Platinum-Oxide Platinum Black. XVIII1. J. Am. Chem. Soc. 1928, 50, (8), 2260-2263.
Classical reagent for cleavage of aryl methyl ethers at 200-220 ° : Ber ., 75, 445 (1942), avoiding the strongly acidic or basic conditions of some alternative methods; see, e.g.: J. Org. Chem., 27, 4660 (1962):
Demethylation of methyl aryl ethers can also be carried out under solvent-free conditions with microwave irradiation: J. Chem. Res. (Synop.), 394 (1999).
Epoxides at ambient temperature in chloroform give chlorohydrins: Synth. Commun., 11, 287 (1981).
In DMF, has been used for the conversion of alkyl tosylates to chlorides at room temperature: J. Am. Chem. Soc., 80, 2726 (1958).
Cleaves N-trityl groups from histidine residues in peptide synthesis: Tetrahedron Lett., 28, 6031 (1987).
Mild acid catalyst, e.g. in the formation of acetals with ethylene glycol: J. Org. Chem., 31, 26 (1966), or 1,3-propanediol: Bull. Soc. Chim. Fr., 2287 (1972); and in the Fischer indole synthesis for acid-sensitive substrates: Synthesis, 645 (1977).