6-Chloropurine is used in the preparation of 9-alkylpurines through alkylation with various substituted alkyl halides in dimethyl sulfoxide. It is also used to prepare 6-succinoaminopurine.
This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.
Aplicaciones
La 6-cloropurina se utiliza en la preparación 9 de-alquilpurinas a través de la alquilación con varios haluros de alquilo sustituidos en dimetilsulfóxido. También se utiliza para preparar 6-succinoaminopurina.
Solubilidad
Soluble en agua caliente y dimetil formamida.
Notas
Incompatibles con agentes oxidantes fuertes.
RUO – Research Use Only
General References:
- Gruzdev, D. A.; Musiyak, V. V.; Chulakov, E. N.; Levit, G. L.; Krasnov, V. P. Synthesis of purine and 2-aminopurine conjugates bearing the fragments of heterocyclic amines at position 6. Chem. Heterocycl. Compd. 2015, 51 (8), 738-744.
- Crossey, K.; Cunningham, R. N.; Redpath, P.; Migaud, M. E. Atom efficient synthesis of pyrimidine and purine nucleosides by ball milling. RSC Adv. 2015, 5 (72), 58116-58119.