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Citas y referencias (23)
Invitrogen™
DQ™ Ovalbumin - Special Packaging
La ovoalbúmina DQ es un sustrato fluorogénico para las proteasas. Se observa un fuerte efecto de supresión de fluorescencia cuandoMás información
| Número de catálogo | Cantidad |
|---|---|
| D12053 | 5 x 1 mg |
Número de catálogo D12053
Precio (USD)
878,04
Each
Cantidad:
5 x 1 mg
Precio (USD)
878,04
Each
La ovoalbúmina DQ es un sustrato fluorogénico para las proteasas. Se observa un fuerte efecto de supresión de fluorescencia cuando las proteínas están fuertemente marcadas con tintes BODIPY. Tras la hidrólisis de ovoalbúmina DQ a péptidos únicos marcados con tinte por proteasas, esta supresión se alivia, lo que produce productos fluorescentes brillantes.
Para uso exclusivo en investigación. No apto para uso en procedimientos diagnósticos.
Especificaciones
Etiqueta o tinteBODIPY™ FL
Línea de productosDQ
Tipo de productoEstudios de presentación y procesamiento y de antígenos
Cantidad5 x 1 mg
Condiciones de envíoTemperatura ambiente
SustratoSustrato de proteasa
Método de detecciónFluorescente
FormularioSólido
Substrate PropertiesSustrato basado en proteínas
Target EnzymeProteasas
Unit SizeEach
Contenido y almacenamiento
Almacenar en el congelador (de -5 a -30 °C) y proteger de la luz.
Preguntas frecuentes
Do you have an alternative for DQ Ovalbumin – Special Packaging (Cat. No. D12053) that can be purchased in the EU?
Citations & References (23)
Citations & References
Abstract
TLR9 signals after translocating from the ER to CpG DNA in the lysosome.
Journal:Nat Immunol
PubMed ID:14716310
'Microbial DNA sequences containing unmethylated CpG dinucleotides activate Toll-like receptor 9 (TLR9). We have found that TLR9 is localized to the endoplasmic reticulum (ER) of dendritic cells (DCs) and macrophages. Because there is no precedent for immune receptor signaling in the ER, we investigated how TLR9 is activated. We show
Carbohydrate oxidation acidifies endosomes, regulating antigen processing and TLR9 signaling.
Journal:J Immunol
PubMed ID:20200279
'Phagocytes kill encapsulated microbes through oxidative cleavage of surface carbohydrates, releasing glycan fragments and microbial contents that serve as ligands for immune receptors, which tailor the immune response against the offending pathogen. The glycan fragments serve as MHC class II (MHC II) ligands and innate receptor agonists, whereas microbial proteins
Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization.
Journal:Nat Immunol
PubMed ID:18604214
'Inhalation of silica crystals causes inflammation in the alveolar space. Prolonged exposure to silica can lead to the development of silicosis, an irreversible, fibrotic pulmonary disease. The mechanisms by which silica and other crystals activate immune cells are not well understood. Here we demonstrate that silica and aluminum salt crystals
Digestion assays in allergenicity assessment of transgenic proteins.
Journal:Environ Health Perspect
PubMed ID:16882518
'The food-allergy risk assessment for transgenic proteins expressed in crops is currently based on a weight-of-evidence approach that holistically considers multiple lines of evidence. This approach recognizes that no single test or property is known to distinguish allergens from nonallergens. The stability of a protein to digestion, as predicted by
Loss-of-function mutations in Rab escort protein 1 (REP-1) affect intracellular transport in fibroblasts and monocytes of choroideremia patients.
Journal:PLoS One
PubMed ID:20027300
'BACKGROUND: Choroideremia (CHM) is a progressive X-linked retinopathy caused by mutations in the CHM gene, which encodes Rab escort protein-1 (REP-1), an escort protein involved in the prenylation of Rabs. Under-prenylation of certain Rabs, as a result of loss of function mutations in REP-1, could affect vesicular trafficking, exocytosis and