Streptozotocin, 97+%

Name: Streptozotocin, 97+%
SKU: J61601.03

Streptozotocin (streptozocin, CAS # 18883-66-4) is an N-nitrosourea antibiotic produced by Streptomyces achromogenes. | CAS: 18883-66-4 | C8H15N3O7 | 265.222 g/mol

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Cantidad:

500 mg

1 g

Número de catálogo J61601.03

también denominado J61601-03

Precio (USD)

Cantidad:

1 g

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Identificadores químicos

CAS18883-66-4

IUPAC Name3-methyl-3-nitroso-1-[(2S,3R,4R,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea

Molecular FormulaC8H15N3O7

InChI KeyZSJLQEPLLKMAKR-GKHCUFPYSA-N

SMILESCN(N=O)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O

Especificaciones Specification Sheet

Hoja de especificaciones

Assay (HPLC)alpha-anomer: 75.0% min.

Appearance (Color)White to pale yellow

Assay (HPLC)>97.0%

FormPowder

Streptozotocin is used to induce Type 1 diabetes for medicine.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Streptozotocin acts as a bactericidal by alkylating DNA and inhibiting DNA synthesis

• Streptozotocin enters cells through glucose transporter 2

Application

• Streptozotocin induces diabetes in experimental animals and can cause acute liver injury

• It is also useful for research on neuroendocrine tumors and carcinoma cells

RUO – Research Use Only

General References:

Duraisamy, A.J.; Mohammad, G.; Kowluru, R.A. Mitochondrial fusion and maintenance of mitochondrial homeostasis in diabetic retinopathy. Biochim Biophys Acta Mol Basis Dis. 2019, 1865(6), 1617-1626.
Zhu, Y.; Han, X.Q.; Sun, X.J.; Yang, R.; Ma, W.Q.; Liu, N.F. Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy. Apoptosis. 2020, (5-6), 321-340.