1-Boc-piperazina, 99 %, Thermo Scientific Chemicals

Name: 1-Boc-piperazina, 99 %, Thermo Scientific Chemicals
SKU: L13363.14

CAS: 57260-71-6 | C9H19N2O2 | 187.26 g/mol

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Cantidad:

5 g

25 g

Número de catálogo L13363.14

también denominado L13363-14

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Cantidad:

25 g

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Identificadores químicos

CAS57260-71-6

Especificaciones Specification Sheet

Hoja de especificaciones

FormCrystals or crystalline powder or lumpy powder or fused solid

Assay (GC)≥98.5%

Appearance (Color)White to cream to yellow

Solution Test5% in ethanol: clear & colourless to yellow

1-Boc-piperazine is useful for the preparation of (m-phenoxy)phenyl substituted piperazine derivatives. It is also used in the synthesis of indazole DNA gyrase inhibitors. Further, it plays an important role in the preparation of alfa,beta-poly(2-oxazoline) lipopolymers through living cationic ring opening polymerization. It is also in involved in Buchwald-Hartwig coupling reactions with aryl halides.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Aplicaciones
La 1-boc-piperazina es útil para la preparación de derivados de piperazina sustituidos con (m-fenoxi)fenilo. También se utiliza en la síntesis de inhibidores de la girasa de ADN de indazol. Además, desempeña un papel importante en la preparación de lipopolímeros alfa,beta-poli(2-oxazolina) a través de la polimerización viva por apertura de anillo catiónico. También participa en reacciones de acoplamiento de Buchwald-Hartwig con haluros de arilo.

Solubilidad
Soluble en acetato de etilo, metanol y agua.

Notas
Higroscópica. Almacenar en lugar fresco. Sensible a la humedad. Incompatible con agentes oxidantes fuertes.

RUO – Research Use Only

General References:

Pd-catalyzed C-N coupling with a variety of bromoarenes, in the presence of NaO-t-Bu and Tri(o-tolyl) phosphine, A12093, provides a route to arylpiperazines of potential pharmacological interest: Tetrahedron Lett., 39, 2219 (1998).
Ba-Salem, A. O.; Shaikh, M. N.; Ullah, N.; Faiz, M. Synthesis and magnetic relaxation properties of new Gd(III) complexes derived from DTPA-bis(amide) conjugates of arylpiperazinyl amines. Inorg. Chem. Commun. 2015, 56, 5-7.
Nemeckova-Herova, D.; Pazdera, P. A Simplified Protocol for Routine Chemoselective Syntheses of Piperazines Substituted in the 1-Position by an Electron Withdrawing Group. Curr. Org. Synth. 2015, 12 (2), 173-179.