Is there training and support available for the Thermo Scientific Orbitrap Isora Mass Spectrometer?
Yes. Thermo Fisher Scientific provides support for the Thermo Scientific Orbitrap Isora Mass Spectrometer through its global service and application support organization. In addition to instrument installation and familiarization, the integrated workflow is designed to simplify adoption by including purpose-built control software for method development and acquisition, the dedicated Thermo Scientific Vanquish Duo UHPLC system, and Thermo Scientific Isotope Discoverer Software for data processing, visualization, and reporting. Customers also have access to Thermo Fisher technical documentation, application resources, and optional training programs to help users become proficient in instrument operation, workflow development, and isotope ratio data analysis.
Is the purchase of the Thermo Scientific Vanquish required for the Thermo Scientific Orbitrap Isora Mass Spectrometer?
The Thermo Scientific Orbitrap Isora Mass Spectrometer is offered as an integrated isotope ratio analysis solution: the standard configuration includes one Orbitrap Isora Mass Spectrometer, a dedicated Thermo Scientific Vanquish Duo UHPLC system configuration, and Thermo Scientific Isotope Discoverer Software. The dedicated Vanquish Duo UHPLC system is an important part of the workflow, providing sample introduction and rapid sample/reference switching to support accurate isotope ratio measurements. This integrated configuration is designed to provide a streamlined path from sample measurement through data processing and final isotope ratio results.
How can the Thermo Scientific Orbitrap Isora Mass Spectrometer complement existing isotope ratio workflows in my laboratory?
The Thermo Scientific Orbitrap Isora Mass Spectrometer complements classical magnetic sector IRMS workflows by enabling isotope ratio measurements directly from intact molecular ions using electrospray ionization and Orbitrap HRAM detection. Rather than requiring conversion of samples into simple gases, it preserves molecular information while allowing analysis of isotope ratios of individual analytes at natural abundance and low-level isotopic enrichment, position-specific isotope analysis, and multiply substituted (clumped) isotopes within a single platform. Depending on the application, the Orbitrap Isora MS can either complement classical IRMS by providing additional molecular context or serve as an alternative workflow for analyses requiring intact molecular isotopic information with simplified sample preparation and with high sensitivity.
What should I consider when choosing between the Thermo Scientific Orbitrap Isora MS and Thermo Scientific Orbitrap Isora Pro MS models?
The primary consideration is the level of analytical performance required. The Thermo Scientific Orbitrap Isora MS offers maximum resolution up to 240,000 (at m/z 200), making it suitable for many isotope ratio applications. The Thermo Scientific Orbitrap Isora Pro MS doubles the maximum resolution up to 480,000 (at m/z 200), providing greater resolving capability for complex isotopologue measurements. Orbitrap Isora Pro MS has additional features that support users beyond conventional HRAM detection and quantification of compounds and isotope-focused analysis, such as: Peptide operation mode, Thermo Scientific TMTpro 35-plex, Bent trap pre-accumulation, and Hybrid-DIA with adaptive RT routine. Both models include the same integrated workflow components—Thermo Scientific Vanquish Duo UHPLC System and Thermo Scientific Isotope Discoverer Software—providing a consistent sample-to-result experience.
Which laboratories are well-suited for the Thermo Scientific Orbitrap Isora Mass Spectrometer?
The Thermo Scientific Orbitrap Isora Mass Spectrometer is well suited for laboratories tackling applications in environmental research, geochemistry, metabolism studies, fluxomic research and food authenticity that are seeking comprehensive isotopic characterization of samples. By combining molecular-level information with isotope ratios, Orbitrap Isora MS can help to address new analytical questions with greater depth and specificity, supporting the following investigations:
- Origin (Where did this molecule come from?)
- Formation (How was it synthesized?)
- Transformation (What chemical or biological processes has it undergone?)
- Identity (Is it authentic, adulterated, or distinguishable from similar materials?)
- Mechanism (Which atoms or pathways are involved in its formation or metabolism?)