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Invitrogen

p70 S6 Kinase Polyclonal Antibody

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View all (77) p70 S6 Kinase antibodies

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Product Details

PA5-28597

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:3,000
View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:1,000
-

Immunocytochemistry (ICC/IF)

1:100-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human p70 S6K. The exact sequence is proprietary.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.7 mg/mL

Amount

70 µg

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7, with 20% glycerol, 1% BSA

Contains

0.01% thimerosal

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2546073

Product Specific Information

Recommended positive controls: 293T, A431, Jurkat, Raji, HeLa.

Predicted reactivity: Mouse (99%), Rat (99%), Xenopus laevis (91%), Rabbit (100%), Chicken (96%), Bovine (100%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

RPS6KB1 (p70S6K) is a serine/threonine kinase with 2 non-identical kinase catalytic domains which phosphorylates several residues of the S6 ribosomal protein. p70 S6 kinase is predominantly localized in the cytoplasm, and is essential in growth factors regulated cell proliferation, pathways involving cell motility, such as metastases, the immune response, and tissue repair. p70 S6 kinase acts downstream of phosphoinositide (PI) 3-kinase, and its main physiological target is the S6 ribosomal protein, which is involved in upregulation of protein synthesis. The kinase activity of p70 S6 kinase leads to an increase in protein synthesis and cell proliferation. Amplification of the region of DNA encoding p70 S6 kinase and overexpression are seen in some breast cancer cell lines.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: 70 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; kinase p70S6K; KS6B1; p70 p70-S6K; p70 ribosomal S6 kinase alpha; p70 S6 kinase alpha; p70 S6K-alpha; p70 S6KA; p70(S6K)-alpha; p70-S6K 1; P70S6K; p70S6K-alpha; P70S6K1; p80-S6K 1; p85 p85S6K; Ribosomal protein S6 kinase beta-1; Ribosomal protein S6 kinase I; ribosomal protein S6 kinase, 70kD, polypeptide 1; ribosomal protein S6 kinase, 70kDa, polypeptide 1; S6 kinase; S6K; S6K-beta-1; S6K1; serine/threonine kinase 14 alpha; Serine/threonine-protein kinase 14A; unnamed protein product

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Gene Aliases: 2610318I15Rik; 4732464A07Rik; 70kDa; AA959758; AI256796; AI314060; p70 S6KA; p70(S6K)-alpha; p70-alpha; p70-S6K; p70/85s6k; p70s6k; PS6K; RPS6KB1; S6K; S6K-beta-1; S6K1; STK14A

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UniProt ID: (Human) P23443, (Mouse) Q8BSK8, (Rat) P67999

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Entrez Gene ID: (Human) 6198, (Mouse) 72508, (Rat) 83840

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Function(s)
nucleotide binding protein kinase activity protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding kinase activity transferase activity protein serine kinase activity ribosomal protein S6 kinase activity transferase activity, transferring phosphorus-containing groups PDZ domain binding peptide binding protein phosphatase 2A binding protein modifying enzyme
Process(es)
autophagosome assembly G1/S transition of mitotic cell cycle behavioral fear response cytoplasmic translation regulation of translation ubiquitin-dependent protein catabolic process apoptotic process signal transduction germ cell development insulin receptor signaling pathway negative regulation of autophagy positive regulation of autophagy peptidyl-serine phosphorylation SCF-dependent proteasomal ubiquitin-dependent protein catabolic process response to nutrient levels cellular response to nutrient levels cellular response to nutrient TOR signaling cellular response to insulin stimulus TORC1 signaling TORC2 signaling negative regulation of apoptotic process protein kinase B signaling long-chain fatty acid import positive regulation of translation positive regulation of mitotic cell cycle positive regulation of translational initiation negative regulation of insulin receptor signaling pathway phosphatidylinositol-mediated signaling modulation of synaptic transmission positive regulation of protein kinase B signaling cellular response to interferon-gamma cellular response to growth factor stimulus cellular response to dexamethasone stimulus negative regulation of TORC2 signaling negative regulation of TORC1 signaling positive regulation of TORC1 signaling negative regulation of extrinsic apoptotic signaling pathway protein phosphorylation cell cycle positive regulation of smooth muscle cell migration phosphorylation response to insulin response to tumor necrosis factor regulation of glucose import positive regulation of skeletal muscle tissue growth positive regulation of smooth muscle cell proliferation cellular response to organic cyclic compound skeletal muscle contraction aging response to nutrient long-term memory response to heat response to wounding response to mechanical stimulus response to toxic substance response to glucose response to organic substance response to organonitrogen compound response to organic cyclic compound skeletal muscle atrophy response to electrical stimulus involved in regulation of muscle adaptation cell migration response to lipopolysaccharide cellular response to hormone stimulus response to testosterone response to glucagon response to drug response to amino acid response to leucine response to peptide hormone response to ethanol response to glucocorticoid
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