Get the convenience, affordability, and power of a pooled population of hepatocytes in a single vial. HEP50 Pooled Human Cryopreserved Hepatocytes are a representative population of 50 different donor hepatocytes that have been isolated using our novel proprietary CellStream Isolation Technology, helping to deliver consistent, predictable results in your drug metabolism studies and other biological assays.

• Pure, highly viable hepatocytes isolated using our CellStream Isolation Technology
• 50 donor hepatocytes, 25 male and 25 female, in each vial
• Verified enzymatic and pathway activity

Each lot is tested for:
• Viability ≥ 75%
• Phase I and II enzyme activities
• Transporter suspension uptake

CellStream Isolation Technology
HEP50 Pooled Human Hepatocytes are produced using our novel proprietary CellStream Isolation Technology. This process eliminates the disadvantages of density gradient fractionation prior to cryopreservation of the pool. Instead, we gently isolate and purify the pre-screened, high-viability, and metabolically-active hepatocytes from other cells and debris. The result is a remarkably pure pooled hepatocyte preparation with high viability for use in drug metabolism studies and other biological assays.

50 donors in one vial
Each vial of HEP50 Pooled Human Hepatocytes contains hepatocytes from 50 individual donors: 25 female and 25 male.

Verified activity
Each pool is characterized for CYP1A2, CYP2B6, CYP2C8, CYP2C9, CYP2C19, CYP2D6, CYP2E1, CYP3A4, CYP3A4/5, and FMO activity, as well as NTCP, OATP1B3, and OATP transporter pathways.

Ready for your drug metabolism experiments
HEP50 Pooled Human Hepatocytes are useful in a wide variety of applications, including intrinsic clearance, transport, toxicology, biochemistry, and cell biology studies.

Note: These products require shipment in liquid nitrogen vapor dewars, so additional fees may apply.