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NOTCH 2 Polyclonal Antibody

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NOTCH 2 Polyclonal Antibody

Product Details

100-401-408

Applications
Tested Dilution
Publications

Western Blot (WB)

1:400-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:500
-

ELISA (ELISA)

1:20,000-1:100,000
-

Immunoprecipitation (IP)

1:400-1:2,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

This whole rabbit serum was prepared by repeated immunizations with a synthetic peptide corresponding to amino acid residues of human Notch 2 located near the N-terminal sequence of the cleaved N intracellular domain (NICD).
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

80 mg/mL

Amount

16 mg

Storage buffer

0.02M potassium phosphate/whole serum, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This antiserum is directed against human NOTCH2. The immunogen epitope is only exposed after gamma secretase cleavage and is not accessible in the uncleaved form. Based on sequences, we expect this antibody to react as well with rat and mouse NOTCH 2. Only one amino acid difference (conservative) occurs in mouse and rat.

Target Information

Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: membrane bound receptor; Neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2; putative cell-fate determining protein; transmembrane protein; unnamed protein product

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Gene Aliases: AGS2; HJCYS; hN2; NOTCH2

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UniProt ID: (Human) Q04721

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Entrez Gene ID: (Human) 4853

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Function(s)
transcription coactivator activity calcium ion binding protein binding enzyme binding signaling receptor activity NF-kappaB binding
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development cell fate determination liver development placenta development heart looping morphogenesis of an epithelial sheet marginal zone B cell differentiation inflammatory response to antigenic stimulus atrioventricular node development pulmonary valve morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process humoral immune response Notch signaling pathway determination of left/right symmetry nervous system development axon guidance cell proliferation positive regulation of cell proliferation organ morphogenesis negative regulation of macromolecule biosynthetic process negative regulation of gene expression positive regulation of keratinocyte proliferation hemopoiesis cell differentiation embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway multicellular organism growth intracellular signal transduction intrahepatic bile duct development wound healing defense response to bacterium regulation of apoptotic process myeloid dendritic cell differentiation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process positive regulation of smooth muscle cell differentiation cardiac septum morphogenesis atrial septum morphogenesis placenta blood vessel development ciliary body morphogenesis positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to tumor cell proximal tubule development glomerular visceral epithelial cell development glomerular capillary formation hepatocyte proliferation liver morphogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of hemopoiesis cholangiocyte proliferation regulation of osteoclast development
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