Tapsigargina
Tapsigargina
Citas y referencias (508)
Invitrogen™

Tapsigargina

Tapsigargina es una lactona sesquiterpénica natural aislada de la planta umbelífera Thapsia garganica. Este promotor tumoral libera Ca2+ de losMás información
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Número de catálogoCantidad
T74581 mg
T745920 x 50 μg
Número de catálogo T7458
Precio (CLP)
178.218
1 mg
Añadir al carro de la compra
Cantidad:
1 mg
Precio (CLP)
178.218
1 mg
Añadir al carro de la compra
Tapsigargina es una lactona sesquiterpénica natural aislada de la planta umbelífera Thapsia garganica. Este promotor tumoral libera Ca2+ de los almacenes intracelulares inhibiendo específicamente el retículo endoplásmico Ca2+-ATPase; no afecta directamente al Ca2+-ATPases, de la membrana plasmática, a la producción de Ins 1,4,5-P3 ni a la actividad de la proteína cinasa C. La tapsigargina también está disponible en un envase de 1 mg, T7458.

Para uso exclusivo en investigación. No apto para uso en procedimientos diagnósticos.

Especificaciones
Tipo de etiquetaSin marcar
Fórmula molecularC34H50O12
Cantidad1 mg
Almacenamiento recomendadoAlmacenar en congelador (de -5 °C a -30 °C)
Condiciones de envíoTemperatura ambiente
Forma físicaSólido
Tipo de productoTapsigargina
Unit Size1 mg
Contenido y almacenamiento
Almacenar en congelador (de - 5 a - 30 °C).

Citations & References (508)

Citations & References
Abstract
Calcium signaling.
Authors:Clapham DE
Journal:Cell
PubMed ID:7834745
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.
Authors:Thastrup O, Cullen PJ, Drøbak BK, Hanley MR, Dawson AP
Journal:Proc Natl Acad Sci U S A
PubMed ID:2138778
Thapsigargin, a tumor-promoting sesquiterpene lactone, discharges intracellular Ca2+ in rat hepatocytes, as it does in many vertebrate cell types. It appears to act intracellularly, as incubation of isolated rat liver microsomes with thapsigargin induces a rapid, dose-dependent release of stored Ca2+. The thapsigargin-releasable pool of microsomal Ca2+ includes the pools ... More
Muscarinic receptors modulate intracellular Ca(2+) concentration in hyaline cells of the chicken basilar papilla.
Authors:Lippe WR, Zirpel L, Stone JS
Journal:J Comp Physiol A Neuroethol Sens Neural Behav Physiol
PubMed ID:12073083
Nonsensory hyaline cells border the sensory epithelium of the auditory end-organ (basilar papilla) in birds and reptiles. Their innervation by cochlear cholinergic efferent fibers and the presence of contractile proteins suggest that hyaline cells may actively regulate basilar membrane mechanics. The cholinergic pharmacology of hyaline cells was studied by measuring ... More
Transmission of cell stress from endoplasmic reticulum to mitochondria: enhanced expression of Lon protease.
Authors:Hori O, Ichinoda F, Tamatani T, Yamaguchi A, Sato N, Ozawa K, Kitao Y, Miyazaki M, Harding HP, Ron D, Tohyama M, M Stern D, Ogawa S
Journal:J Cell Biol
PubMed ID:12082077
'The rat homologue of a mitochondrial ATP-dependent protease Lon was cloned from cultured astrocytes exposed to hypoxia. Expression of Lon was enhanced in vitro by hypoxia or ER stress, and in vivo by brain ischemia. These observations suggested that changes in nuclear gene expression (Lon) triggered by ER stress had ... More
Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response.
Authors:Kokame K, Kato H, Miyata T
Journal:J Biol Chem
PubMed ID:11112790
'Herp is a 54-kDa membrane protein in the endoplasmic reticulum (ER). The mRNA expression level of Herp is increased by the accumulation of unfolded proteins in the ER. Transcriptional changes designed to deal with this type of ER stress is called the unfolded protein response (UPR). Most mammalian UPR-target genes ... More
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