Vitamin D3, 99%, crystalline

Vitamin D3, 99%, CAS # 67-97-0, also known as cholecalciferol, is a steroid hormone produced in the skin or obtained from dietary sources. It is an essential mediator of bone calcium metabolism. | CAS: 67-97-0 | C27H44O | 384.648 g/mol

Catalog Number	Quantity	Packaging
140940050	5 g	Glass bottle

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Catalog number 140940050

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Chemical Identifiers

CAS67-97-0

IUPAC Name(1S,3E)-3-{2-[(1R,3aS,4E,7aR)-7a-methyl-1-[(2R)-6-methylheptan-2-yl]-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexan-1-ol

Molecular FormulaC27H44O

InChI KeyQYSXJUFSXHHAJI-FVUVGDFOSA-N

SMILESCC(C)CCC[C@@H](C)[C@H]1CC[C@H]2\C(CCC[C@]12C)=C\C=C1/C[C@@H](O)CCC1=C

Specifications

Specific optical rotation+105° to +112° (25°C, 589 nm) (c=0.8, ethanol)

Appearance (Color)White to light yellow

Appearance (Form)Crystalline powder or crystals

Infrared spectrumConforms

Melting point81°C to 87°C

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

• Vitamin D3 is a steroid hormone generated in the skin when the 7-dehydrocholesterol interacts with ultraviolet irradiation. It can also be found in several types of food for daily intake.

• Vitamin D3 binds to vitamin D receptors, thus modulating gene expression

Applications

• In in vivo studies, vitamin D3 has been implicated in the maintenance of blood calcium and phosphorus levels, bone metabolism, metabolic functions, and transcription regulation

• It modulates the proliferation and differentiation of both normal and cancer cells

• It presents in vitro antiproliferative and antimetastatic activities on breast, colon, and prostate cancer cells

RUO – Research Use Only

General References:

Chakraborti, C. K. Vitamin D as a promising anticancer agent. Indian J Pharmacol. 2011 Apr;43(2):113-20. doi: 10.4103/0253-7613.77335.
Meyer, O.; Dawson-Hughes, B.; Sidelnikov, E.; Egli, A.; Grob, D.; Staehelin, H. B.; Theiler, G.; Kressig, R. W.; Simmen, H. P.; Theiler, R.; Bischoff-Ferrari, H. A. Calcifediol versus vitamin D3 effects on gait speed and trunk sway in young postmenopausal women: a double-blind randomized controlled trial. Osteoporos Int. 2015, 26 (1), 373-381.
Mehlig, L. M.; Garve, C.; Tauer, J. T.; Suttorp, M.; Bauer, A. Inhibitory effects of imatinib on vitamin D3 synthesis in human keratinocytes. Mol. Med. Rep. 2015, 11 (4), 3143-3147.