Hydroxychloroquine sulfate, 98%

Name: Hydroxychloroquine sulfate, 98%
SKU: 263010250

Hydroxychloroquine sulfate, CAS # 747-36-4, is a chemical compound with antiparasitic, antiviral, and anti-rheumatic activities. | CAS: 747-36-4 | C₁₈H₂₆ClN₃O·H₂SO₄ | 433.96 g/mol

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25 g

100 g

Packaging:

Glass bottle

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Catalog number 263010250

Price (EUR)

Quantity:

25 g

Packaging:

Glass bottle

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Chemical Identifiers

CAS747-36-4

IUPAC Name2-({4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino)ethan-1-ol; sulfuric acid

Molecular FormulaC18H28ClN3O5S

InChI KeyJCBIVZZPXRZKTI-UHFFFAOYNA-N

SMILESOS(O)(=O)=O.CCN(CCO)CCCC(C)NC1=C2C=CC(Cl)=CC2=NC=C1

Specifications

Specification Sheet

Appearance (Color)White to off-white

UV spectrophotometry>=97.5 % (on dried basis)

Sulfated ash=<0.2 %

Loss on drying=<2 % (105°C, 2 h)

Chloride (Cl)=<350 ppm

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

Hydroxychloroquine sulfate shows antimalarial activity against malaria parasites mainly in the intra-erythrocytic phase of its life cycle. It acts by inhibiting the heme polymerase inside the food vacuole of the parasites
It shows an inhibitory activity in autophagy preventing the lysosome fusion with the autophagosome
Some studies demonstrated that hydroxychloroquine sulfate, due to its antiviral activity can restrict HIV infection in vitro

Applications

Hydroxychloroquine sulfate displays antiviral and anti-rheumatic activities
In vitro and in vivo experiments have been performed to investigate the role of hydroxychloroquine sulfate in the treatment of SARS-CoV-2 disease
Hydroxychloroquine sulfate can be used in immunofluorescence assays to evaluate the antiviral mechanisms in dengue virus-2 infection. In this disease, this compound can activate the innate immune response

RUO – Research Use Only